{"id":4106,"date":"2022-08-24T10:53:25","date_gmt":"2022-08-24T13:53:25","guid":{"rendered":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021?page_id=4106"},"modified":"2022-09-22T16:39:50","modified_gmt":"2022-09-22T19:39:50","slug":"pele-pequeno-principe-research-institute","status":"publish","type":"page","link":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/pele-pequeno-principe-research-institute\/?lang=en","title":{"rendered":"Pel\u00e9 Pequeno Pr\u00edncipe Research Institute"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4106\" class=\"elementor elementor-4106\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-67f0181 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"67f0181\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0fb2775\" data-id=\"0fb2775\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c63e66 elementor-widget-mobile__width-initial e-transform elementor-invisible elementor-widget elementor-widget-image\" data-id=\"5c63e66\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:19,&quot;sizes&quot;:[]},&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-163,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:98,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:17,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-34,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"768\" height=\"594\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/Artboard-4-2-768x594.png\" class=\"attachment-medium_large size-medium_large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/Artboard-4-2-768x594.png 768w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/Artboard-4-2-300x232.png 300w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/Artboard-4-2.png 886w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50c601e elementor-widget elementor-widget-spacer\" data-id=\"50c601e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-container{--container-widget-width:100%}.e-container>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));-ms-flex-item-align:stretch;align-self:stretch;-ms-flex-negative:0;flex-shrink:0}.e-container>.elementor-widget-spacer>.elementor-widget-container,.e-container>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-container>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c74f9ae elementor-widget__width-initial elementor-absolute elementor-invisible elementor-widget elementor-widget-image\" data-id=\"c74f9ae\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"671\" height=\"702\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/faculdades_foto_abertura.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/faculdades_foto_abertura.png 671w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/faculdades_foto_abertura-287x300.png 287w\" sizes=\"(max-width: 671px) 100vw, 671px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ca5bdfe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ca5bdfe\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-32166c0\" data-id=\"32166c0\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-380fd18 elementor-widget elementor-widget-image\" data-id=\"380fd18\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/logo_instituto_pele-pryc1vf8grys7x539hbycc8g92uvamk6yta5z893j8.png\" title=\"logo_instituto_pele\" alt=\"logo_instituto_pele\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ebeedd7 elementor-widget__width-initial elementor-absolute elementor-widget elementor-widget-text-editor\" data-id=\"ebeedd7\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<div class=\"box-abertura\"><h1>\u201cVaccines [against COVID-19] were developed in record time \u2013 a victory of science and human ingenuity.\u201d<\/h1><div style=\"line-height: 18px;\">Ant\u00f3nio Guterres, <br \/>secretary-general of the UN<\/div><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d6db9d elementor-widget elementor-widget-spacer\" data-id=\"4d6db9d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e353226\" data-id=\"e353226\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-09151b1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"09151b1\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-99b229e\" data-id=\"99b229e\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9575119 e-transform elementor-widget-mobile__width-inherit elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"9575119\" data-element_type=\"widget\" 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href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/INSTITUTO_numeros_01.png\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"INSTITUTO_numeros_01\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDQ2OSwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA5XC9JTlNUSVRVVE9fbnVtZXJvc18wMS5wbmcifQ%3D%3D\">\n\t\t\t\t\t\t\t<img width=\"1294\" height=\"704\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/INSTITUTO_numeros_01.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/INSTITUTO_numeros_01.png 1294w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/INSTITUTO_numeros_01-300x163.png 300w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/INSTITUTO_numeros_01-1024x557.png 1024w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/INSTITUTO_numeros_01-768x418.png 768w\" sizes=\"(max-width: 1294px) 100vw, 1294px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dc8a8e e-transform elementor-widget-mobile__width-inherit elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"6dc8a8e\" data-element_type=\"widget\" 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href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/pesquisa_indicadores_mobile_01.png\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"pesquisa_indicadores_mobile_01\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDQ3MSwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA5XC9wZXNxdWlzYV9pbmRpY2Fkb3Jlc19tb2JpbGVfMDEucG5nIn0%3D\">\n\t\t\t\t\t\t\t<img width=\"601\" height=\"1801\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/pesquisa_indicadores_mobile_01.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/pesquisa_indicadores_mobile_01.png 601w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/pesquisa_indicadores_mobile_01-100x300.png 100w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/pesquisa_indicadores_mobile_01-342x1024.png 342w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/pesquisa_indicadores_mobile_01-513x1536.png 513w\" sizes=\"(max-width: 601px) 100vw, 601px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-795275c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"795275c\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2c69905\" data-id=\"2c69905\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-493705b elementor-widget elementor-widget-spacer\" data-id=\"493705b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8d2aff7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8d2aff7\" data-element_type=\"section\" id=\"6-1\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3dac692\" data-id=\"3dac692\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-42b1f20 elementor-widget elementor-widget-spacer\" data-id=\"42b1f20\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef13d3c elementor-widget elementor-widget-heading\" data-id=\"ef13d3c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-xxl\">Producing the future\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aea85b3 elementor-widget elementor-widget-text-editor\" data-id=\"aea85b3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The COVID-19 pandemic has shed light to the strategic importance of scientific research to preserve life. Through coronavirus vaccines, it also showed in practice how new treatments need to be based on science: the present work of scientists is what shapes the future of healthcare.<\/p><p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); background-color: var( --e-global-color-7aea5b9 );\">The appreciation of the close link between the laboratory and clinical and surgical practice led to the creation of the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute. Inaugurated in 2006, it was born from a comprehensive conception of children\u2019s health: it complemented care (offered by the Hospital since 1919) and education (offered by the College since 2003), thus reinforcing the Complex\u2019s commitment to the cause of childhood and adolescence. The plan was to create a research institute, but permeated with a social concern \u2013 as all scientists should be, according to the wise words of one of the great personalities in the area, a key figure for the creation of the Pequeno Pr\u00edncipe Innovation Office: the physical chemist S\u00e9rgio Mascarenhas, who died in 2021.<\/span><\/p><p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); background-color: var( --e-global-color-7aea5b9 );\">Fifteen years after its creation, the Institute recorded, even with the adjustments required by the pandemic times, an exceptional volume of scientific production. In 2021, researchers doubled the number of publications compared to the average of the previous four years. Several works started in 2020 \u2013 to improve the diagnosis, characterization and treatment of COVID-19 \u2013 were intensified. Among them, the creation of a serum with antibodies against the disease. The relevance of many studies was recognized in A1-level journals, the highest of Qualis Capes (Brazilian official system for classifying scientific production), such as <em>Science Immunology<\/em>, <em>Nature Immunology<\/em>, <em>Cancer Research<\/em>, among others.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a2f0bd2 elementor-widget elementor-widget-text-editor\" data-id=\"a2f0bd2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Such achievements were the outcome of some strategy changes:<\/p><ul><li>With clinical work still affected by social distancing, which makes tracking participants difficult, the Institute emphasized projects that could be conducted remotely.<\/li><li>The researchers dedicated themselves to the analysis of data already obtained, searched for information in international public databases and produced works of systematic narrative reviews, meta-analyses (statistical analyzes based on the results of multiple scientific studies) and more complex works, such as Big Data <em>in silico<\/em> (genomic, proteomic and transcriptomic analyses).<\/li><li>Cooperation with national and foreign institutions was strengthened. Thus, the Institute benefited from findings obtained by research partners in Brazil and abroad, in projects related to COVID-19 and pediatric cancer.<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93f5b05 elementor-widget elementor-widget-spacer\" data-id=\"93f5b05\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-99e575a\" data-id=\"99e575a\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-522a990 elementor-widget elementor-widget-spacer\" data-id=\"522a990\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e7e5ba elementor-widget elementor-widget-text-editor\" data-id=\"6e7e5ba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The present work of scientists is shaping the future of healthcare.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0c992c elementor-widget elementor-widget-image\" data-id=\"f0c992c\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"768\" height=\"511\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-768x511.jpeg\" class=\"attachment-medium_large size-medium_large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-768x511.jpeg 768w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-300x200.jpeg 300w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-1024x681.jpeg 1024w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-1536x1022.jpeg 1536w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4.jpeg 2000w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4502dbb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4502dbb\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5863c98\" data-id=\"5863c98\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-460e6db elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"460e6db\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6664662\" data-id=\"6664662\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e265928 elementor-widget elementor-widget-text-editor\" data-id=\"e265928\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h5><span style=\"color: #006c88;\"><b>Maturity reached at the age of 15<\/b><\/span><\/h5><p>In normal times the event would be held in an auditorium, with seminars followed by laboratory visits. But the 15 years of inauguration of the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute were completed in the midst of one of the worst months of COVID-19, in April 2021. The celebration, then, had to be online: a live section with about 100 participants recalled the main projects in progress, highlighted the importance of the research developed and highlighted the academic training offered.<\/p><p>Even with all participants isolated, each one on their computer screen, the professionals were moved as they recalled the most relevant conquests and the companions that helped to build the beginning of this journey in favor of childhood and adolescence.<\/p><p>In its first 15 years, the Research Institute has trained almost 130 masters and doctors, published more than 350 scientific articles and produced knowledge that has already benefited thousands of children: an exam added to the main bloodspot test (<em>TP53 <\/em>p.R337H) to discover the second hereditary genetic mutation (<em>XAF1 <\/em>p.E134*) associated with a predisposition to the development of a type of childhood cancer that has the highest incidence worldwide in Paran\u00e1 (adrenocortical carcinoma), the fifth largest worldwide study for the detection of primary immunodeficiencies (errors of innate immunity), studies to improve detection of attention-deficit\/hyperactivity disorder (ADHD) \u2013 and so many other advances<span style=\"background-color: var( --e-global-color-4e6ff5f ); color: var( --e-global-color-47363a9 ); font-family: var( --e-global-typography-7c40bf1-font-family ), Sans-serif; font-size: var( --e-global-typography-7c40bf1-font-size ); font-weight: var( --e-global-typography-7c40bf1-font-weight ); letter-spacing: var( --e-global-typography-7c40bf1-letter-spacing ); word-spacing: var( --e-global-typography-7c40bf1-word-spacing );\">.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65dd7d0 elementor-widget elementor-widget-image-carousel\" data-id=\"65dd7d0\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;1&quot;,&quot;navigation&quot;:&quot;none&quot;,&quot;effect&quot;:&quot;fade&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-widget-image-carousel .swiper-container{position:static}.elementor-widget-image-carousel .swiper-container .swiper-slide figure{line-height:inherit}.elementor-widget-image-carousel .swiper-slide{text-align:center}.elementor-image-carousel-wrapper:not(.swiper-container-initialized) .swiper-slide{max-width:calc(100% \/ var(--e-image-carousel-slides-to-show, 3))}<\/style>\t\t<div class=\"elementor-image-carousel-wrapper swiper-container\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper swiper-image-stretch\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/15_anos_IPP_GERAL_1-1024x576.jpeg\" alt=\"15_anos_IPP_GERAL_1\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/15_anos_IPP_GERAL_2-1024x576.jpeg\" alt=\"15_anos_IPP_GERAL_2\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/15_anos_IPP_GERAL_3-1024x576.jpeg\" alt=\"15_anos_IPP_GERAL_3\" \/><\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-be174d8 elementor-widget elementor-widget-spacer\" data-id=\"be174d8\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-571bd70\" data-id=\"571bd70\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5586a86 elementor-testimonial--align-left elementor-testimonial--skin-default elementor-testimonial--layout-image_inline elementor-arrows-yes elementor-pagination-type-bullets elementor-widget elementor-widget-testimonial-carousel\" data-id=\"5586a86\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:250,&quot;sticky_effects_offset&quot;:250,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;show_arrows&quot;:&quot;yes&quot;,&quot;pagination&quot;:&quot;bullets&quot;,&quot;speed&quot;:500,&quot;autoplay&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;loop&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;space_between&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;space_between_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;space_between_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]}}\" data-widget_type=\"testimonial-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/plugins\/elementor-pro\/assets\/css\/widget-carousel.min.css\">\t\t<div class=\"elementor-swiper\">\n\t\t\t<div class=\"elementor-main-swiper swiper-container\">\n\t\t\t\t<div class=\"swiper-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cI have to congratulate the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute for 15 years of dedication to science and for helping to save lives.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Pel\u00e9<\/span><span class=\"elementor-testimonial__title\">patron of the Research Institute<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cHere, I could see the care, the restlessness, the edginess and the desire of everyone to do more for children, families, employees and for our community.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Ety Cristina Forte Carneiro<\/span><span class=\"elementor-testimonial__title\">director-general of the Research Institute<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201c\u201cIn 1969, Pel\u00e9 said that the Brazilian people could not forget about the children. And that is what we have been doing since 2006.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Bonald Cavalcante de Figueiredo<\/span><span class=\"elementor-testimonial__title\">scientific director of the Institute<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cDoing science is fueling yourself with the energy that pulses with each new discovery and each life that we have the potential to impact with it.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Carolina Prando<\/span><span class=\"elementor-testimonial__title\">director of Translational Medicine at the Institute<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cI would like to quote Saint-Exup\u00e9ry\u2019s statement: \u2018Those who pass by us do not go alone, they do not leave us alone. They leave a little of themselves, they take a little of us\u2019.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Mara L\u00facia Cordeiro<\/span><span class=\"elementor-testimonial__title\">director of Institutional Relations at the Institute, in memory of doctor Nilson Santos, one of the creators of the Pequeno Pr\u00edncipe Complex unit<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cI would like to congratulate everyone, in the certainty that, together, we build and will build a science committed to human dignity, planetary health and the love of life.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Patricia Forte Rauli<\/span><span class=\"elementor-testimonial__title\">director-general of Pequeno Pr\u00edncipe College<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-left\"><\/i>\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Anterior<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-right\"><\/i>\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Pr\u00f3ximo<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-789d77f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"789d77f\" data-element_type=\"section\" id=\"6-2\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-405e3b6\" data-id=\"405e3b6\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f35a799 elementor-widget elementor-widget-spacer\" data-id=\"f35a799\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dd496cd elementor-widget elementor-widget-heading\" data-id=\"dd496cd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xxl\">The featured research<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a6f2b6 elementor-widget elementor-widget-spacer\" data-id=\"3a6f2b6\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2378247 elementor-widget elementor-widget-heading\" data-id=\"2378247\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-large\">COVID-19 under review\n<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0483ac5 elementor-widget elementor-widget-text-editor\" data-id=\"0483ac5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The knowledge accumulated about COVID-19 in the first year of the pandemic was fundamental to improve the treatment of patients infected with the coronavirus and to fight the spread of this virus. However, many aspects of SARS-CoV-2 need to continue to be studied. The Pel\u00e9 Pequeno Pr\u00edncipe Research Institute joins the efforts of the world scientific community to:<\/p><ol><li>Understand in details the behavior of different variants of SARS-CoV-2, including in people with other diseases.<\/li><li>Investigate consequences of therapies in use.<\/li><li>Develop ways to avoid serious cases after contagion.<\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64758f1 elementor-widget elementor-widget-spacer\" data-id=\"64758f1\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4c6b9b2\" data-id=\"4c6b9b2\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-abfe1f2 elementor-widget elementor-widget-spacer\" data-id=\"abfe1f2\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe411de elementor-widget elementor-widget-image\" data-id=\"fe411de\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/Pesquisa_COVID_Dra_Carol_Prando-5-psfegmh6siwq35rv4maxiikyx4gzheex66m6q6vi9w.jpeg\" title=\"Pesquisa_COVID_Dra_Carol_Prando (5)\" alt=\"Pesquisa_COVID_Dra_Carol_Prando (5)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b2c088 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1b2c088\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-01bad94\" data-id=\"01bad94\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f6b75a8 elementor-widget elementor-widget-spacer\" data-id=\"f6b75a8\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6891db8 elementor-widget elementor-widget-heading\" data-id=\"6891db8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-large\">What do these studies look for?\n<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38ffe98 elementor-widget elementor-widget-toggle\" data-id=\"38ffe98\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-toggle{text-align:left}.elementor-toggle .elementor-tab-title{font-weight:700;line-height:1;margin:0;padding:15px;border-bottom:1px solid #d4d4d4;cursor:pointer;outline:none}.elementor-toggle .elementor-tab-title .elementor-toggle-icon{display:inline-block;width:1em}.elementor-toggle .elementor-tab-title .elementor-toggle-icon svg{-webkit-margin-start:-5px;margin-inline-start:-5px;width:1em;height:1em}.elementor-toggle .elementor-tab-title .elementor-toggle-icon.elementor-toggle-icon-right{float:right;text-align:right}.elementor-toggle .elementor-tab-title .elementor-toggle-icon.elementor-toggle-icon-left{float:left;text-align:left}.elementor-toggle .elementor-tab-title .elementor-toggle-icon .elementor-toggle-icon-closed{display:block}.elementor-toggle .elementor-tab-title .elementor-toggle-icon .elementor-toggle-icon-opened{display:none}.elementor-toggle .elementor-tab-title.elementor-active{border-bottom:none}.elementor-toggle .elementor-tab-title.elementor-active .elementor-toggle-icon-closed{display:none}.elementor-toggle .elementor-tab-title.elementor-active .elementor-toggle-icon-opened{display:block}.elementor-toggle .elementor-tab-content{padding:15px;border-bottom:1px solid #d4d4d4;display:none}@media (max-width:767px){.elementor-toggle .elementor-tab-title{padding:12px}.elementor-toggle .elementor-tab-content{padding:12px 10px}}.e-container>.elementor-widget-toggle{width:var(--container-widget-width,100%)}<\/style>\t\t<div class=\"elementor-toggle\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5971\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-5971\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Investigate the relationship between genetic alterations and the coronavirus<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5971\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5971\"><p>A study looks at how genetic inheritance and immunological factors are associated with the infection, which can help define protocols and new therapies. The project is part of <a href=\"https:\/\/www.covidhge.com\/\" target=\"_blank\" rel=\"noopener\">COVID Human Genetic Effort<\/a>, an initiative with the participation of scientists from around the world. In Brazil, it is coordinated by a researcher from the Institute.<\/p><p>Another group aims at the macrophage activation syndrome, a rare genetic disease that affects the immune system and causes excessive proliferation of defense cells, called macrophages. In partnership with the Pontifical Catholic University of Paran\u00e1 (PUCPR), scientists analyzed lung tissue from people who died as a result of COVID-19 and concluded that the genetic alteration may be a risk factor for those infected with the coronavirus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5972\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"tab\" aria-controls=\"elementor-tab-content-5972\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Enabling new treatments for metabolic syndrome<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5972\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5972\"><p>Metabolic syndrome \u2013 a collection of risk factors involving cardiovascular problems, obesity and insulin resistance \u2013 increases the risk of heart disease, stroke and diabetes. It also increases the chances of death in those infected with SARS-CoV-2. A project by the Research Institute aims to elucidate the mechanisms of the syndrome to identify new opportunities for the treatment of this condition.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5973\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"tab\" aria-controls=\"elementor-tab-content-5973\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Identify the role of miRNAs in viral interaction<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5973\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5973\"><p>Small types of RNA (molecules that synthesize proteins), miRNAs play a significant role in regulating the response to the virus. They alert the immune system but can also lead to an overreaction that causes inflammation and favors SARS-CoV-2. The systematic review of studies on the topic, conducted together with researchers from PUCPR, showed that the analysis of miRNAs helps to define risk groups and that the molecule can be the target of future treatments against COVID-19.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5974\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"tab\" aria-controls=\"elementor-tab-content-5974\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Measuring radiation in examinations of children with suspected COVID-19<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5974\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5974\"><p>Even before the diagnosis of COVID-19 is confirmed, small patients with symptoms that demand more attention are frequently submitted to a CT scan of the chest. The exam helps to better analyze the health picture but exposes children to extremely high doses of radiation \u2013 which, in some cases, can cause cancer. The Institute began measuring the values of these doses to compare them to established levels nationally and internationally, in addition to finding out whether CT scans performed without sedation increase radiation exposure.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5975\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"tab\" aria-controls=\"elementor-tab-content-5975\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Tracing how COVID-19 evolves in patients with errors of innate immunity<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5975\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5975\"><p>Errors of Innate Immunity are a group of over 400 rare genetic disorders that affect the functioning of the immune system and can lead to serious infections. The study with 121 participants, developed in partnership with universities in Brazil and abroad, concluded that illnesses were not a determining factor for greater severity of COVID-19, except in patients who had comorbidities.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5976\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"tab\" aria-controls=\"elementor-tab-content-5976\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">To know the clinical and laboratory evolution of COVID-19 in children and adolescents<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5976\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5976\"><p>At the beginning of the pandemic, the pediatric age group was less affected by the coronavirus. This perception has changed over time, so it is relevant to collect and process all available information about the clinical manifestations and evolution of the disease in children and adolescents.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5977\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"tab\" aria-controls=\"elementor-tab-content-5977\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Determine effects of infection over the first year post-COVID-19<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5977\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5977\"><p>In addition to the symptoms that accompany acute infection, it is now known that the coronavirus also has long-term effects. The project evaluates the cases of health professionals infected by SARS-CoV-2 and surveys sequelae one year after infection.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5978\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"tab\" aria-controls=\"elementor-tab-content-5978\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Identify indicators of worsening COVID-19<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5978\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5978\"><p>A meta-analysis conducted in partnership with other Brazilian institutions reviewed and compared the results of 12 studies on biomarkers \u2013 biological signals that indicate changes in the body \u2013 associated with the immune system and related to inflammatory conditions. The study showed that low lymphocyte counts are linked to severe cases of COVID-19, which means that it is possible to identify patients with the possibility of a critical evolution through a blood count.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5979\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"tab\" aria-controls=\"elementor-tab-content-5979\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Develop part of a lung with a 3D printer to test drugs<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5979\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5979\"><p>The project, conducted in partnership with the Federal University of Technology of Paran\u00e1 (UTFPR, abbreviation in Portuguese), inaugurates bioprinting at the Institute. It will reproduce an in vitro alveolus (functional unit of the lungs) to be used in lung-acting drug tests, including against COVID-19. Bioprinting uses biogel as a raw material, a substance formed by protein and water mixed with nutrients. The compound allows the growth of cells, giving rise to human tissues. In the future, scientists hope to be able to print entire organs.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-59710\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"tab\" aria-controls=\"elementor-tab-content-59710\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Assess whether drugs on the market reduce viral load in infected people<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-59710\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-59710\"><p>A randomized clinical trial has begun to compare the performance of two existing drugs on the market, clarithromycin and ivermectin, to see if they are able to reduce the burden of SARS-CoV-2 in critically ill patients. Currently, drugs are recommended primarily as antimicrobials and antiparasitic.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-42f94a4\" data-id=\"42f94a4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e7517e elementor-widget elementor-widget-text-editor\" data-id=\"2e7517e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The Institute\u2019s researchers joined forces with the world scientific community to advance knowledge about the coronavirus.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-015377c elementor-widget elementor-widget-image\" data-id=\"015377c\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/covid-virus-3d-modeling_freepik-przr9rhn4w5ifo522p6gwt1g2koh2cmeyxui6cm2x0.jpeg\" title=\"covid-virus-3d-modeling_freepik\" alt=\"covid-virus-3d-modeling_freepik\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7bd5574 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7bd5574\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f85fa32\" data-id=\"f85fa32\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f216748 elementor-widget elementor-widget-spacer\" data-id=\"f216748\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f654370\" data-id=\"f654370\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f672208 elementor-widget elementor-widget-spacer\" data-id=\"f672208\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5b00e46 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5b00e46\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-21f1e7b\" data-id=\"21f1e7b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64286e3 elementor-widget elementor-widget-spacer\" data-id=\"64286e3\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7eac687 elementor-widget elementor-widget-heading\" data-id=\"7eac687\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">Antibodies to neutralize the coronavirus<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a43e8a elementor-widget elementor-widget-text-editor\" data-id=\"3a43e8a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>One of the projects of the Research Institute in the area of COVID-19 is the development of antibodies against the coronavirus from the plasma of horses. Started in 2020, the study concluded its preliminary phases in 2021.<\/p><p>After the production of a serum by the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute and the Center for Immunobiological Production and Research (CPPI, which is part of the State Foundation for Healthcare, Funeas, an agency of the Paran\u00e1 State Department of Health), the raw horse serum is sent for antibody extraction at Ezequiel Dias Foundation (Funed), in Minas Gerais, to later confirm its efficiency in blocking SARS-CoV-2 in mice genetically modified to contract COVID-19. The analysis of the efficiency and safety of the serum will be conducted in laboratories of the Center for Immunobiological Production and Research and the Oswaldo Cruz Foundation (Fiocruz) in Paran\u00e1.<\/p><p>The treatment was conceived by researchers from Pequeno Pr\u00edncipe based on the concept of passive immunity, in which the patient receives ready-made antibodies instead of producing them in the body. It is indicated for people without immunity against the coronavirus \u2013 both unvaccinated and immunized who have been unable to produce antibodies.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-314cdcd elementor-widget elementor-widget-spacer\" data-id=\"314cdcd\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8823fe4\" data-id=\"8823fe4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e23244f elementor-widget elementor-widget-image\" data-id=\"e23244f\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/Dr_Bonald-6-pryhu2oa9p0n002jcnw6ykf226s8ft1s312ju1v6mc.jpg\" title=\"Dr_Bonald (6)\" alt=\"Dr_Bonald (6)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0f35cb3 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0f35cb3\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5569397\" data-id=\"5569397\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4de2f22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4de2f22\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-7c97b0c\" data-id=\"7c97b0c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-08c7a67 elementor-widget elementor-widget-text-editor\" data-id=\"08c7a67\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h5 style=\"color: #006c88;\"><strong>As fases do projeto<\/strong><\/h5>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5f2c9c elementor-widget elementor-widget-image\" data-id=\"d5f2c9c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"instituto_fases_projeto\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTI4MiwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA3XC9pbnN0aXR1dG9fZmFzZXNfcHJvamV0by5qcGcifQ%3D%3D\">\n\t\t\t\t\t\t\t<img width=\"783\" height=\"1024\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto-783x1024.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto-783x1024.jpg 783w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto-229x300.jpg 229w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto-768x1005.jpg 768w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto.jpg 862w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-f2278ae elementor-widget elementor-widget-spacer\" data-id=\"f2278ae\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-936505d\" data-id=\"936505d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e02b74d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e02b74d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a5a56ae\" data-id=\"a5a56ae\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-152f8aa elementor-widget elementor-widget-spacer\" data-id=\"152f8aa\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8bbd947 elementor-widget elementor-widget-heading\" data-id=\"8bbd947\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">Genetic and immunological causes of severe forms of COVID-19<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce8560 elementor-widget elementor-widget-text-editor\" data-id=\"9ce8560\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Two findings published in 2021 in the journal <em>Science<\/em> grew out of research by the COVID Human Genetic Effort consortium, an international project that covers hundreds of hospitals around the world and which, in Brazil, has a group led by the Research Institute. The articles showed that more than 10% of young, healthy people who develop severe forms of COVID-19 produce antibodies that attack not the virus, but the immune system itself (autoantibody). Another 3.5%, at least, carry a specific type of genetic mutation that affects the immune response.<\/p><p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); background-color: var( --e-global-color-7aea5b9 );\">In both cases, patients do not have adequate type I interferon, a group of 17 proteins essential to protect the body. This is either because the proteins were neutralized by the autoantibodies or because they were not produced in sufficient quantities due to a faulty gene. Such situations help explain why some people develop more severe forms of COVID-19 than others in the same age group. The good news is that patients with these characteristics can be treated with medications already available on the market, reducing the risk of death from COVID-19.<\/span><\/p><p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); background-color: var( --e-global-color-7aea5b9 );\">When looking at critically ill patients, the study found that 10% of them (the vast majority man, 95%) developed autoantibodies at the beginning of the infection. The finding has an impact on plasma treatments of convalescent humans: if the donor has autoantibodies, their plasma cannot be used to treat other people.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-03237a3\" data-id=\"03237a3\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d74a4d7 elementor-widget elementor-widget-spacer\" data-id=\"d74a4d7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ad3a23 elementor-widget elementor-widget-image\" data-id=\"5ad3a23\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.covidhge.com\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/logo_CHGE-przqj8hm97srmdbj51od7qg3khb1n5d65xalitmnzi.png\" title=\"logo_CHGE\" alt=\"logo_CHGE\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7267e elementor-widget elementor-widget-spacer\" data-id=\"ad7267e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ee867de elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ee867de\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1a6f00e\" data-id=\"1a6f00e\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fb50f7 elementor-widget elementor-widget-spacer\" data-id=\"4fb50f7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f643494 elementor-widget elementor-widget-heading\" data-id=\"f643494\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">Big Data expansion<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a6fd6a3 elementor-widget elementor-widget-text-editor\" data-id=\"a6fd6a3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Created in 2020, the Big Data research group gained new members. They help the team in jobs that use high-capacity computers to analyze information from open access international databases in different areas.<\/p><p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); background-color: var( --e-global-color-7aea5b9 );\">In 2021, the group produced articles on the effect of smoking on congenital malformations; the incidence of bladder and lung cancer in the American continent; and the immunology of the adrenocortical carcinoma (the outer part of the adrenal glands). The results of this latest study support a new project to develop a therapeutic vaccine against adrenocortical carcinoma. This is overly complex research, conducted in live cells stored in the Pequeno Pr\u00edncipe Biobank, where human tissues are kept for internal studies and donations.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f683f94 elementor-widget elementor-widget-spacer\" data-id=\"f683f94\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2b8b1af elementor-hidden-mobile\" data-id=\"2b8b1af\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-115db4b elementor-widget elementor-widget-spacer\" data-id=\"115db4b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dfec57b elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"dfec57b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8f8338b\" data-id=\"8f8338b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aceabfc elementor-widget elementor-widget-spacer\" data-id=\"aceabfc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-30b6792\" data-id=\"30b6792\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cd3402a elementor-widget elementor-widget-spacer\" data-id=\"cd3402a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ad87f26 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ad87f26\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3a9ee96\" data-id=\"3a9ee96\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-733981c elementor-widget elementor-widget-spacer\" data-id=\"733981c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b70f806 elementor-widget elementor-widget-heading\" data-id=\"b70f806\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">Projects started in 2021<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24abf0c elementor-widget elementor-widget-text-editor\" data-id=\"24abf0c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>In its seven lines of research, the Institute has 96 projects under development. Below are some highlights by line of research.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e79f588 elementor-widget elementor-widget-toggle\" data-id=\"e79f588\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2421\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-2421\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Complex diseases and oncogenetics<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2421\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2421\"><p><strong>Project topic:<\/strong> genetic analysis of tissues with Ewing sarcoma<br \/><strong>Objective:<\/strong> to identify gene alterations in patients who develop Ewing sarcoma, a type of cancer that occurs in or around the bones of children and young adults.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2422\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"tab\" aria-controls=\"elementor-tab-content-2422\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Cell therapy and pharmacology<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2422\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2422\"><p><strong>Project topic:<\/strong> neuronal precursor cell microRNA therapy in the treatment of Parkinson\u2019s disease<br \/><strong>Objective:<\/strong> as part of the Ministry of Health\u2019s Innovative Platforms in Advanced Therapies program, the project for the development of new treatments for Parkinson\u2019s disease, which received funds in 2020, had its experiments started in 2021. The project seeks to the development of a safe biological nanodrug, from products derived from neuronal precursors obtained from the differentiation of stem cells from the human umbilical cord.<\/p><p><strong>Project topic:<\/strong> optimization of obtaining neuronal precursors and their derivatives in hybrid material \u2013 biomaterial and graphene<br \/><strong>Objective:<\/strong> to optimize the acquisition of neuronal precursors and their derivatives in material hybrid (membrane biopolymer NFBX incorporated with nanoparticles in graphene) for increase cell production and expansion in the development of new therapies for neurodegenerative and neurodevelopmental diseases. Cells sense the microenvironment around them through signaling chemical or by the interpretation of physical forces, which can be generated either internally and externally in response to physical properties such as stiffness or substrate elasticity, cellular contractility or even the force generated by neighboring cells. This ability of cells to transform mechanical stimuli in chemicals responses is referred to as mechanotransduction and it is essential for modulate cell behavior, influencing destiny of cells in relation to its proliferation, survival, differentiation and even in regeneration process in fabrics and repair in injuries. On the other hand, graphene has a two-dimensional structure, high area in surface, high electric conductivity, chemistry stability and flexible properties. These features allow graphene to be able to immobilize substances such as metals, drugs, fluorescent probes and cells, attracting interest in regenerative medicine. Recent studies demonstrate that graphene, or materials based on graphene, promote adhesion, proliferation and differentiation of various cell types, including the stem cells.<\/p><p><strong>Project topic:<\/strong> extraction of the beta-glucan compound from medicinal mushrooms<br \/><strong>Objective:<\/strong> to study low-cost means to extract beta-glucan, present in some types of mushrooms. It activates the immune system and has direct action in the treatment of mucositis, inflammation of the inner part of the mouth and throat that can affect patients undergoing chemotherapy treatments.<\/p><p><strong>Project topic:<\/strong> effects of kojic and glycolic acids on melanin production<br \/><strong>Objective:<\/strong> to evaluate the effects of these two acids on cells that produce melanin (a protein that determines skin color), to verify if they have the potential to reduce this production and, thus, be used in treatments against melasma (hyperpigmentation that causes dark spots on the skin).<\/p><p><strong>Project topic:<\/strong> bone marrow transplantation in children with bone marrow failure<br \/><strong>Objective:<\/strong> to evaluate the profile of patients up to 5 years of age who underwent hematopoietic stem cell transplantation from 1992 to 2020 in three Brazilian institutions, to show survival results and to describe early or late complications after surgery.<\/p><p><strong>Project topic:<\/strong> stem cell transplantation in patients with inborn errors of metabolism<br \/><strong>Objective:<\/strong> to evaluate survival and complications after bone marrow transplantation in children with inborn errors of metabolism. This genetic condition impairs the proper functioning of protein synthesis and can cause everything from vomiting and frequent infections to gastric diseases and growth problems. Unprecedented in Brazil, the analysis focuses on transplants in six pediatric hospitals in the country, between 1988 and 2020.<\/p><p><strong>Project topic:<\/strong> relapse of acute leukemias after transplantation<br \/><strong>Objective:<\/strong> to analyze the reappearance of the disease and risk factors in patients under 18 years of age who underwent donor hematopoietic stem cell transplantation. The focus of the survey is children and adolescents undergoing the procedure between 2010 and 2019 in three Brazilian pediatric centers.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2423\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"tab\" aria-controls=\"elementor-tab-content-2423\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Neurosciences<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2423\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2423\"><p><strong>Project topic:<\/strong> effects of toxic mercury on neuron formation<br \/><strong>Objective:<\/strong> to analyze the effects of a toxic type of mercury on the growth and differentiation of neurons obtained from stem cells, in search of an explanation for Parkinson\u2019s disease.<\/p><p><strong>Project topic:<\/strong> neurological and genetic profiles of patients with mucopolysaccharidosis type III in Brazil<br \/><strong>Objective:<\/strong> to study the impact of mucopolysaccharidosis type III, also called Sanfilippo syndrome, on the brain and behavior of children and adolescents.<\/p><p><strong>Project topic:<\/strong> comparison of the diagnosis of autism spectrum disorder (ASD) in developed and developing countries desenvolvidos e em desenvolvimento<br \/><strong>Objective:<\/strong> the research project aims to evaluate the methods, first symptoms and who observes them (pediatricians, parents or teachers) of ASD in children, and to compare the results of developed countries (with upper middle income) with those of developing countries (with low income). Such research can clarify which symptoms are most important and who notices them first, contributing to help preliminary treatment.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2424\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"tab\" aria-controls=\"elementor-tab-content-2424\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Imaging, radiation protection, and radiotherapy <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2424\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2424\"><p><strong>Project topic:<\/strong> digital image quality and radiographic techniques in pediatrics<br \/><strong>Objective:<\/strong> to quantify radiation doses in children undergoing radiographs, obtain high-quality images with the lowest possible radiation, and create a pediatric protocol for the use of diverse types of digital equipment.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2425\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"tab\" aria-controls=\"elementor-tab-content-2425\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Microbiology and infectious diseases<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2425\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2425\"><p><strong>Project topic:<\/strong> bacteria that cause infections and are drug resistant<br \/><strong>Objective:<\/strong> to know the epidemiology of the bacteria <em>Staphylococcus aureus<\/em> resistant to the antibiotic methicillin in order to adopt more effective control measures for this microorganism, which is one of the biggest causes of nosocomial infection in the world. The project works together with the <strong><a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/?page_id=4032&amp;lang=en#:~:text=Advancements%20in%20antimicrobial%20control\">Antimicrobial Stewardship Program of Pequeno Pr\u00edncipe Hospital<\/a><\/strong>.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2426\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"tab\" aria-controls=\"elementor-tab-content-2426\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Molecular medicine and bioinformatics<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2426\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2426\"><p><strong>Project topic:<\/strong> search for therapeutic response markers in acute lymphoblastic leukemia (ALL)<br \/><strong>Objective:<\/strong> to evaluate genetic alterations of leukemic cells and their gene expression in pediatric patients with ALL, at diagnosis and also during treatment, seeking to identify possible initial markers of therapeutic response. Simultaneously, the enteric microbiota of patients will be evaluated, also at diagnosis and throughout treatment, to understand the role of this microbiota in the patient\u2019s response to treatment and in their susceptibility to infections. Thus, it will also be possible to evaluate the interaction of genetic and immunological factors with the microbiota and the importance of these interactions in determining therapeutic success.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a1879df elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-toggle\" data-id=\"a1879df\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1691\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-1691\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Complex diseases and oncogenetics<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1691\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1691\"><p><strong>Project topic:<\/strong> genetic analysis of tissues with Ewing sarcoma<br \/><strong>Objective:<\/strong> to identify gene alterations in patients who develop Ewing sarcoma, a type of cancer that occurs in or around the bones of children and young adults.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1692\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"tab\" aria-controls=\"elementor-tab-content-1692\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Terapia celular e farmacol\u00f3gica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1692\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1692\"><p><strong>Project topic:<\/strong> neuronal precursor cell microRNA therapy in the treatment of Parkinson\u2019s disease<br \/><strong>Objective:<\/strong> as part of the Ministry of Health\u2019s Innovative Platforms in Advanced Therapies program, the project for the development of new treatments for Parkinson\u2019s disease, which received funds in 2020, had its experiments started in 2021. The project seeks to the development of a safe biological nanodrug, from products derived from neuronal precursors obtained from the differentiation of stem cells from the human umbilical cord.<\/p><p><strong>Project topic:<\/strong> optimization of obtaining neuronal precursors and their derivatives in hybrid material \u2013 biomaterial and graphene<br \/><strong>Objective:<\/strong> to optimize the acquisition of neuronal precursors and their derivatives in material hybrid (membrane biopolymer NFBX incorporated with nanoparticles in graphene) for increase cell production and expansion in the development of new therapies for neurodegenerative and neurodevelopmental diseases. Cells sense the microenvironment around them through signaling chemical or by the interpretation of physical forces, which can be generated either internally and externally in response to physical properties such as stiffness or substrate elasticity, cellular contractility or even the force generated by neighboring cells. This ability of cells to transform mechanical stimuli in chemicals responses is referred to as mechanotransduction and it is essential for modulate cell behavior, influencing destiny of cells in relation to its proliferation, survival, differentiation and even in regeneration process in fabrics and repair in injuries. On the other hand, graphene has a two-dimensional structure, high area in surface, high electric conductivity, chemistry stability and flexible properties. These features allow graphene to be able to immobilize substances such as metals, drugs, fluorescent probes and cells, attracting interest in regenerative medicine. Recent studies demonstrate that graphene, or materials based on graphene, promote adhesion, proliferation and differentiation of various cell types, including the stem cells.<\/p><p><strong>Project topic:<\/strong> extraction of the beta-glucan compound from medicinal mushrooms<br \/><strong>Objective:<\/strong> to study low-cost means to extract beta-glucan, present in some types of mushrooms. It activates the immune system and has direct action in the treatment of mucositis, inflammation of the inner part of the mouth and throat that can affect patients undergoing chemotherapy treatments.<\/p><p><strong>Project topic:<\/strong> effects of kojic and glycolic acids on melanin production<br \/><strong>Objective:<\/strong> to evaluate the effects of these two acids on cells that produce melanin (a protein that determines skin color), to verify if they have the potential to reduce this production and, thus, be used in treatments against melasma (hyperpigmentation that causes dark spots on the skin).<\/p><p><strong>Project topic:<\/strong> bone marrow transplantation in children with bone marrow failure<br \/><strong>Objective:<\/strong> to evaluate the profile of patients up to 5 years of age who underwent hematopoietic stem cell transplantation from 1992 to 2020 in three Brazilian institutions, to show survival results and to describe early or late complications after surgery.<\/p><p><strong>Project topic:<\/strong> stem cell transplantation in patients with inborn errors of metabolism<br \/><strong>Objective:<\/strong> to evaluate survival and complications after bone marrow transplantation in children with inborn errors of metabolism. This genetic condition impairs the proper functioning of protein synthesis and can cause everything from vomiting and frequent infections to gastric diseases and growth problems. Unprecedented in Brazil, the analysis focuses on transplants in six pediatric hospitals in the country, between 1988 and 2020.<\/p><p><strong>Project topic:<\/strong> relapse of acute leukemias after transplantation<br \/><strong>Objective:<\/strong> to analyze the reappearance of the disease and risk factors in patients under 18 years of age who underwent donor hematopoietic stem cell transplantation. The focus of the survey is children and adolescents undergoing the procedure between 2010 and 2019 in three Brazilian pediatric centers.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1693\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"tab\" aria-controls=\"elementor-tab-content-1693\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Neurosciences<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1693\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1693\"><p><strong>Project topic:<\/strong> effects of toxic mercury on neuron formation<br \/><strong>Objective:<\/strong> to analyze the effects of a toxic type of mercury on the growth and differentiation of neurons obtained from stem cells, in search of an explanation for Parkinson\u2019s disease.<\/p><p><strong>Project topic:<\/strong> neurological and genetic profiles of patients with mucopolysaccharidosis type III in Brazil<br \/><strong>Objective:<\/strong> to study the impact of mucopolysaccharidosis type III, also called Sanfilippo syndrome, on the brain and behavior of children and adolescents.<\/p><p><strong>Tema do projeto:<\/strong> comparison of the diagnosis of autism spectrum disorder (ASD) in developed and developing countries<br \/><strong>Objective:<\/strong> the research project aims to evaluate the methods, first symptoms and who observes them (pediatricians, parents or teachers) of ASD in children, and to compare the results of developed countries (with upper middle income) with those of developing countries (with low income). Such research can clarify which symptoms are most important and who notices them first, helping to help preliminary treatment.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1694\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"tab\" aria-controls=\"elementor-tab-content-1694\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Imaging, radiation protection, and radiotherapy<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1694\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1694\"><p><strong>Project topic:<\/strong> digital image quality and radiographic techniques in pediatrics<br \/><strong>Objective:<\/strong> to quantify radiation doses in children undergoing radiographs, obtain high-quality images with the lowest possible radiation, and create a pediatric protocol for the use of diverse types of digital equipment.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1695\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"tab\" aria-controls=\"elementor-tab-content-1695\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Microbiology and infectious diseases<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1695\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1695\"><p><strong>Project topic:<\/strong> bacteria that cause infections and are drug resistant<br \/><strong>Objective:<\/strong> to know the epidemiology of the bacteria Staphylococcus aureus resistant to the antibiotic methicillin in order to adopt more effective control measures for this microorganism, which is one of the biggest causes of nosocomial infection in the world. The project works together with the Antimicrobial Stewardship Program of Pequeno Pr\u00edncipe Hospital.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1696\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"tab\" aria-controls=\"elementor-tab-content-1696\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Molecular medicine and bioinformatics<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1696\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1696\"><p><strong>Project topic:<\/strong> search for therapeutic response markers in acute lymphoblastic leukemia (ALL)<br \/><strong>Objective:<\/strong> to evaluate genetic alterations of leukemic cells and their gene expression in pediatric patients with ALL, at diagnosis and also during treatment, seeking to identify possible initial markers of therapeutic response. Simultaneously, the enteric microbiota of patients will be evaluated, also at diagnosis and throughout treatment, to understand the role of this microbiota in the patient\u2019s response to treatment and in their susceptibility to infections. Thus, it will also be possible to evaluate the interaction of genetic and immunological factors with the microbiota and the importance of these interactions in determining therapeutic success.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1092026 elementor-widget elementor-widget-spacer\" data-id=\"1092026\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7880fb1\" data-id=\"7880fb1\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-de4914d elementor-widget elementor-widget-image\" data-id=\"de4914d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/IPP-psfepcfa76uhsx3u7e0bnbcxbthkwb19pcid0ly0jo.jpeg\" title=\"IPP\" alt=\"IPP\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e6ba14 elementor-widget elementor-widget-image\" data-id=\"3e6ba14\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/IPP-10-psfeqnf7owmtxf7kkybo3zhz131xl67ujt4n0g0bwk.jpeg\" title=\"IPP (10)\" alt=\"IPP (10)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a96c81a elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"a96c81a\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2ebe0f5\" data-id=\"2ebe0f5\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-db8018b elementor-widget elementor-widget-spacer\" data-id=\"db8018b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e66c122\" data-id=\"e66c122\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-65dc68b elementor-widget elementor-widget-spacer\" data-id=\"65dc68b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-254018c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"254018c\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a8b23d4\" data-id=\"a8b23d4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-59eba1a elementor-widget elementor-widget-spacer\" data-id=\"59eba1a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bca3269 elementor-widget elementor-widget-heading\" data-id=\"bca3269\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xxl\">Partnerships in Brazil and worldwide<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e223f7 elementor-widget elementor-widget-text-editor\" data-id=\"5e223f7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Science is a collective activity, which relies heavily on collaboration among scientists. The Pel\u00e9 Pequeno Pr\u00edncipe Research Institute has maintained several partnerships with national and international institutions for years, that have already yielded much fruit.<\/p><p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); background-color: var( --e-global-color-7aea5b9 );\">In 2021, an agreement was signed with Thales, a French technology company, for the creation of algorithms capable of indicating cancer prognoses through artificial intelligence. The Institute also expanded its partnership with the University of Kharkiv (Ukraine) on a project to measure radiation doses in children undergoing X-rays<\/span><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); background-color: var( --e-global-color-7aea5b9 );\">.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0f5389d elementor-hidden-mobile\" data-id=\"0f5389d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e16da95 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e16da95\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-b6f5abc\" data-id=\"b6f5abc\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ffa6565 elementor-widget elementor-widget-spacer\" data-id=\"ffa6565\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c2ab21 elementor-widget elementor-widget-heading\" data-id=\"6c2ab21\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">National partners<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-433cd1b elementor-widget elementor-widget-text-editor\" data-id=\"433cd1b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li>A.C.Camargo Cancer Center<\/li><li>Centro de Inova\u00e7\u00e3o e Ensaios Pr\u00e9-Cl\u00ednicos (CIEnP)<\/li><li>Centro de Produ\u00e7\u00e3o e Pesquisa de Imunobiol\u00f3gicos (CPPI)<\/li><li>Faculdades Pequeno Pr\u00edncipe<\/li><li>Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) \u2013 Instituto Carlos Chagas (ICC\/Fiocruz Paran\u00e1, in Curitiba)<\/li><li>Instituto de Tratamento do C\u00e2ncer Infantil (Itaci, in S\u00e3o Paulo)<\/li><li>Instituto Nacional de C\u00e2ncer (Inca)<\/li><li>Hospital de Amor (Barretos)<\/li><li>Hospital de Cl\u00ednicas da UFPR<\/li><li>Hospital de Cl\u00ednicas de Porto Alegre<\/li><li>Hospital do C\u00e2ncer de Cascavel (Uopeccan)<\/li><li>Hospital Erasto Gaertner<\/li><li>Hospital Israelita Albert Einstein (S\u00e3o Paulo)<\/li><li>Hospital Nossa Senhora das Gra\u00e7as<\/li><li>Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie<\/li><li>Novos Arranjos de Pesquisa e Inova\u00e7\u00e3o (NAPI-Gen\u00f4mica, in Guarapuava, state of Paran\u00e1)<\/li><li>Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR)<\/li><li>Rede Gen\u00f4mica Nacional<\/li><li>Universidade Cat\u00f3lica de Pelotas (UCPel)<\/li><li>Universidade Ceuma<\/li><li>Universidade de S\u00e3o Paulo (USP)<\/li><li>Universidade do Estado de Santa Catarina (Udesc)<\/li><li>Universidade Estadual de Londrina (UEL)<\/li><li>Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF)<\/li><li>Universidade Estadual do Paran\u00e1 (Unespar)<\/li><li>Universidade Federal da Grande Dourados (UFGD)<\/li><li>Universidade Federal de Pernambuco (UFPE)<\/li><li>Universidade Federal de Santa Catarina (UFSC)<\/li><li>Universidade Federal de Santa Maria (UFSM)<\/li><li>Universidade Federal do Delta do Parna\u00edba (UFDPar)<\/li><li>Universidade Federal do Maranh\u00e3o (UFMA)<\/li><li>Universidade Federal do Paran\u00e1 (UFPR)<\/li><li>Universidade Federal do Rec\u00f4ncavo da Bahia (UFRB)<\/li><li>Universidade Federal do Rio de Janeiro (UFRJ)<\/li><li>Universidade Paranaense (Unipar)<\/li><li>Universidade Tecnol\u00f3gica Federal do Paran\u00e1 (UTFPR)<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ee59145\" data-id=\"ee59145\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-154856d elementor-widget elementor-widget-spacer\" data-id=\"154856d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e935ede elementor-widget elementor-widget-image\" data-id=\"e935ede\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/08\/IPP-7.jpeg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"IPP (7)\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MzI1NSwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA4XC9JUFAtNy5qcGVnIn0%3D\">\n\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/IPP-7-pt5v9he843miggmi2yjwn2e2c4wse20akjhdfuxyfc.jpeg\" title=\"IPP (7)\" alt=\"IPP (7)\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-26d25dc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"26d25dc\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7e39356\" data-id=\"7e39356\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3049c0c elementor-widget elementor-widget-spacer\" data-id=\"3049c0c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-be83cdc elementor-widget elementor-widget-heading\" data-id=\"be83cdc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">International partners<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-84f5ca8 elementor-widget elementor-widget-text-editor\" data-id=\"84f5ca8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li>Emory University (USA)<\/li><li>Georgetown University (USA)<\/li><li>Georgia State University (USA)<\/li><li>Howard University (USA)<\/li><li>Icahn Mount Sinai School of Medicine (USA)<\/li><li>Imagine Institute (France)<\/li><li>INSERM U1163, Paris 5 (France)<\/li><li>Institute of Molecular and Cellular Pharmacology of Valbonne (France)<\/li><li>King\u2019s College (England)<\/li><li>Loma Linda University Medical Center (USA)<\/li><li>National Cancer Institute (USA)<\/li><li>National Institute of Pediatrics (Mexico)<\/li><li>Rockefeller University (USA)<\/li><li>St. Jude Children\u2019s Research Hospital (USA)<\/li><li>Thales Group (France)<\/li><li>University of Antioquia (Colombia)<\/li><li>University of Applied Sciences (Germany)<\/li><li>University of Cagliari (Italy)<\/li><li>University of California (USA)<\/li><li>University of Kharkiv (Ukraine)<\/li><li>University of the Western Cape (South Africa)<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7c149ac elementor-widget elementor-widget-image\" data-id=\"7c149ac\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/6.2.5-Parcerias-internacionais.png\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"6.2.5 Parcerias internacionais\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDUyMiwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA5XC82LjIuNS1QYXJjZXJpYXMtaW50ZXJuYWNpb25haXMucG5nIn0%3D\">\n\t\t\t\t\t\t\t<img width=\"800\" height=\"387\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/6.2.5-Parcerias-internacionais.png\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/6.2.5-Parcerias-internacionais.png 904w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/6.2.5-Parcerias-internacionais-300x145.png 300w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/09\/6.2.5-Parcerias-internacionais-768x371.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ded0afc elementor-widget elementor-widget-spacer\" data-id=\"ded0afc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e8ad236 elementor-hidden-mobile\" data-id=\"e8ad236\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-16064b5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"16064b5\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7201b0c\" data-id=\"7201b0c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-136150e elementor-widget elementor-widget-spacer\" data-id=\"136150e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0cc03ed elementor-widget elementor-widget-heading\" data-id=\"0cc03ed\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xxl\">Impact articles\n<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5697e89 elementor-widget elementor-widget-text-editor\" data-id=\"5697e89\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>See the articles by researchers from the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute published in 2021.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b01467 elementor-widget elementor-widget-text-editor\" data-id=\"9b01467\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Adrenocortical Carcinoma Steroid Profiles: In Silico Pan-Cancer Analysis of TCGA Data Uncovers Immunotherapy Targets for Improved Outcomes. <em>Frontiers in Endocrinology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3389\/fendo.2021.672319\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fendo.2021.672319<\/a><\/p><p>The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model. <em>Cancer Research<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1750\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1750<\/a><\/p><p>Pharmacological profile and effects of mitotane in adrenocortical carcinoma. <em>British Journal of Clinical Pharmacology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/bcp.14721\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/bcp.14721<\/a><\/p><p>Newborn Screening for the Detection of the TP53 R337H Variant and Surveillance for Early Diagnosis of Pediatric Adrenocortical Tumors: Lessons Learned and Way Forward. <em>Cancers<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/cancers13236111\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/cancers13236111<\/a><\/p><p>Curative therapy for hemoglobinopathies: an International Society for Cell &amp; Gene Therapy Stem Cell Engineering Committee review comparing outcomes, accessibility and cost of ex vivo stem cell gene therapy versus allogeneic hematopoietic stem cell transplantation. <em>Cytotherapy<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jcyt.2021.09.003\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jcyt.2021.09.003<\/a><\/p><p>Nursing diagnosis after hematopoietic stem cell transplant due to Fanconi anemia. <em>Revista Brasileira de Enfermagem<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1590\/0034-7167-2019-0864\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1590\/0034-7167-2019-0864<\/a><\/p><p>Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. II: CAR-T cell therapy for patients with CD19+ acute lymphoblastic leukemia. <em>Hematology, Transfusion and Cell Therapy<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.htct.2021.09.002\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.htct.2021.09.002<\/a><\/p><p>Ocular Manifestations in Patients with Fanconi Anemia: A Single Center Experience Including 106 Patients. <em>The Journal of Pediatrics<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jpeds.2021.11.013\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jpeds.2021.11.013<\/a><\/p><p>Kidney complications in 107 Fanconi anemia patients submitted to hematopoietic cell transplantation. <em>European Journal of Pediatrics<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1007\/s00431-021-04263-0\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1007\/s00431-021-04263-0<\/a><\/p><p>Impact of mother donor, peripheral blood stem cells and measurable residual disease on outcomes after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in children with acute leukaemia. <em>Bone Marrow Transplantation<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1038\/s41409-021-01453-0\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41409-021-01453-0<\/a><\/p><p>Analysis of baseline characteristics, disease burden and long-term follow-up of 167 patients with Paroxysmal Nocturnal Hemoglobinuria at a single center in Brazil. <em>Blood Cells, Molecules, and Diseases<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bcmd.2021.102605\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.bcmd.2021.102605<\/a><\/p><p>Therapy-related acute myeloid leukemia with KMT2A-SNX9 gene fusion associated with a hyperdiploid karyotype after hemophagocytic lymphohistiocytosis. <em>Cancer Genetics<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.cancergen.2021.05.001\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.cancergen.2021.05.001<\/a><\/p><p>Outcomes After Haploidentical Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide: A Systematic Review and Meta-Analysis Comparing Myeloablative with Reduced-Intensity Conditioning Regimens and Bone Marrow with Peripheral Blood Stem Cell Grafts. <em>Transplantation and Cellular Therapy<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jtct.2021.06.011\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jtct.2021.06.011<\/a><\/p><p>International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome. <em>Journal of Allergy and Clinical Immunology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2021.04.036\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jaci.2021.04.036<\/a><\/p><p>The impact of donor-specific anti-human leukocyte antigen antibodies in salvage haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide in patients with nonmalignant disorders. <em>HLA<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/tan.14277\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/tan.14277<\/a><\/p><p>Mortality among pediatric hematopoietic stem cell transplantation patients: Report from a single center in southern Brazil. <em>Pediatric Transplantation<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/petr.13944\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/petr.13944<\/a><\/p><p>A case series of medication-related fibrovascular hyperplasia following hematopoietic stem cell transplantation for Fanconi anemia. <em>Pediatric Transplantation<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/petr.13947\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/petr.13947<\/a><\/p><p>Self-perception of periodontal health status among individuals with Fanconi anemia. <em>Hematology, Transfusion and Cell 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Risk Factors for Autism in Children Requiring Neonatal Intensive Care Unit. <em>Neuropediatrics<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1055\/s-0041-1726401\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1055\/s-0041-1726401<\/a><\/p><p>Neuropsychological and behavioural profiles of students with intellectual development disorder on parents and teachers\u2019 perceptions. <em>Journal of Intellectual Disability Research<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/jir.12837\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/jir.12837<\/a><\/p><p>Clinical and Neurological Course of Tuberous Sclerosis Complex in Children and Adolescents. <em>Annals of Pediatrics &amp; Child Health<\/em>.<br \/><a href=\"https:\/\/www.jscimedcentral.com\/Pediatrics\/pediatrics-9-1225.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/www.jscimedcentral.com\/Pediatrics\/<br \/>pediatrics-9-1225.pdf<\/a><\/p><p>GABAA receptor encephalitis associated with human parvovirus B19 virus infection: Case report. <em>Medicine<\/em>.<br \/><a href=\"http:\/\/dx.doi.org\/10.1097\/MD.0000000000026324\" target=\"_blank\" rel=\"noopener\">http:\/\/dx.doi.org\/10.1097\/MD.0000000000026324<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a153c8 elementor-widget elementor-widget-spacer\" data-id=\"1a153c8\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-96991ab\" data-id=\"96991ab\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c8dec57 elementor-widget elementor-widget-image\" data-id=\"c8dec57\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/Dra_Libera-2-e1658238988225-przppu3chrjwhg0wtc6g85j2om7qvynesepv597zug.jpeg\" title=\"Dra_Libera (2)\" alt=\"Dra_Libera (2)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-582153e elementor-widget elementor-widget-image\" data-id=\"582153e\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:420,&quot;sticky_effects_offset&quot;:420,&quot;sticky_parent&quot;:&quot;yes&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/IPP_2021-1-przq9f2avicyczkwgswn67ms7lp18ye3hc012s6qsm.jpeg\" title=\"IPP_2021 (1)\" alt=\"IPP_2021 (1)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b178fe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1b178fe\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e0b9bb6\" data-id=\"e0b9bb6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-26b99fb elementor-widget elementor-widget-spacer\" data-id=\"26b99fb\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u201cVaccines [against COVID-19] were developed in record time \u2013 a victory of science and human ingenuity.\u201d Ant\u00f3nio Guterres, secretary-general of the UN Producing the future The COVID-19 pandemic has shed light to the strategic importance of scientific research to preserve life. Through coronavirus vaccines, it also showed in practice how new treatments need to be [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/pages\/4106"}],"collection":[{"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/comments?post=4106"}],"version-history":[{"count":100,"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/pages\/4106\/revisions"}],"predecessor-version":[{"id":5424,"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/pages\/4106\/revisions\/5424"}],"wp:attachment":[{"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/media?parent=4106"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}