{"id":24,"date":"2022-05-19T12:49:16","date_gmt":"2022-05-19T15:49:16","guid":{"rendered":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/?page_id=24"},"modified":"2022-09-22T16:33:37","modified_gmt":"2022-09-22T19:33:37","slug":"instituto-pesquisa-pele-pequeno-principe","status":"publish","type":"page","link":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/instituto-pesquisa-pele-pequeno-principe\/","title":{"rendered":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"24\" class=\"elementor elementor-24\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-67f0181 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"67f0181\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0fb2775\" data-id=\"0fb2775\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c63e66 elementor-widget-mobile__width-initial e-transform elementor-invisible elementor-widget elementor-widget-image\" data-id=\"5c63e66\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:19,&quot;sizes&quot;:[]},&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-163,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:98,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:17,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-34,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/instituto_ilustra_abertura-pryc88s09p6534kgf0b4d3wi4tdup6f3yqdnmql7oi.png\" title=\"instituto_ilustra_abertura\" alt=\"instituto_ilustra_abertura\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50c601e elementor-widget elementor-widget-spacer\" data-id=\"50c601e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-container{--container-widget-width:100%}.e-container>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));-ms-flex-item-align:stretch;align-self:stretch;-ms-flex-negative:0;flex-shrink:0}.e-container>.elementor-widget-spacer>.elementor-widget-container,.e-container>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-container>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c74f9ae elementor-widget__width-initial elementor-absolute elementor-invisible elementor-widget elementor-widget-image\" data-id=\"c74f9ae\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"671\" height=\"702\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/faculdades_foto_abertura.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/faculdades_foto_abertura.png 671w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/faculdades_foto_abertura-287x300.png 287w\" sizes=\"(max-width: 671px) 100vw, 671px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ca5bdfe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ca5bdfe\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-32166c0\" data-id=\"32166c0\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-380fd18 elementor-widget elementor-widget-image\" data-id=\"380fd18\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/logo_instituto_pele-pryc1vf8grys7x539hbycc8g92uvamk6yta5z893j8.png\" title=\"logo_instituto_pele\" alt=\"logo_instituto_pele\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ebeedd7 elementor-widget__width-initial elementor-absolute elementor-widget elementor-widget-text-editor\" data-id=\"ebeedd7\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<div class=\"box-abertura\"><h1>\u201cAs vacinas [contra a COVID-19] foram desenvolvidas em tempo recorde \u2013 uma vit\u00f3ria da ci\u00eancia e da engenhosidade humana.\u201d<\/h1><div style=\"line-height: 18px;\">Ant\u00f3nio Guterres, <br \/>secret\u00e1rio-geral da ONU<\/div><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d6db9d elementor-widget elementor-widget-spacer\" data-id=\"4d6db9d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e353226\" data-id=\"e353226\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-09151b1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"09151b1\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-99b229e\" data-id=\"99b229e\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9575119 e-transform elementor-widget-mobile__width-inherit elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"9575119\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-150,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-21,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/indicadores_instituto_01.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"indicadores_instituto_01\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTI0OSwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA3XC9pbmRpY2Fkb3Jlc19pbnN0aXR1dG9fMDEuanBnIn0%3D\">\n\t\t\t\t\t\t\t<img width=\"1292\" height=\"707\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/indicadores_instituto_01.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/indicadores_instituto_01.jpg 1292w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/indicadores_instituto_01-300x164.jpg 300w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/indicadores_instituto_01-1024x560.jpg 1024w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/indicadores_instituto_01-768x420.jpg 768w\" sizes=\"(max-width: 1292px) 100vw, 1292px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dc8a8e e-transform elementor-widget-mobile__width-inherit elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"6dc8a8e\" data-element_type=\"widget\" data-settings=\"{&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-150,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-21,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/pesquisa_indicadores_mobile_01.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"pesquisa_indicadores_mobile_01\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjA1NywidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA3XC9wZXNxdWlzYV9pbmRpY2Fkb3Jlc19tb2JpbGVfMDEuanBnIn0%3D\">\n\t\t\t\t\t\t\t<img width=\"601\" height=\"1801\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/pesquisa_indicadores_mobile_01.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/pesquisa_indicadores_mobile_01.jpg 601w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/pesquisa_indicadores_mobile_01-100x300.jpg 100w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/pesquisa_indicadores_mobile_01-342x1024.jpg 342w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/pesquisa_indicadores_mobile_01-513x1536.jpg 513w\" sizes=\"(max-width: 601px) 100vw, 601px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-795275c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"795275c\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2c69905\" data-id=\"2c69905\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-493705b elementor-widget elementor-widget-spacer\" data-id=\"493705b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8d2aff7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8d2aff7\" data-element_type=\"section\" id=\"6-1\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3dac692\" data-id=\"3dac692\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-42b1f20 elementor-widget elementor-widget-spacer\" data-id=\"42b1f20\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef13d3c elementor-widget elementor-widget-heading\" data-id=\"ef13d3c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-xxl\">Produzindo o futuro \n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aea85b3 elementor-widget elementor-widget-text-editor\" data-id=\"aea85b3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>A pandemia de COVID-19 evidenciou a import\u00e2ncia estrat\u00e9gica da pesquisa cient\u00edfica para preservar a vida. Por meio das vacinas contra o coronav\u00edrus, tamb\u00e9m mostrou na pr\u00e1tica como os novos tratamentos precisam basear-se na ci\u00eancia: o trabalho presente dos cientistas \u00e9 que molda o futuro da assist\u00eancia em sa\u00fade.<\/p><p>A valoriza\u00e7\u00e3o do elo estreito entre o laborat\u00f3rio e a pr\u00e1tica cl\u00ednica e cir\u00fargica levou \u00e0 cria\u00e7\u00e3o do Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe. Inaugurado em 2006, ele nasceu de uma concep\u00e7\u00e3o integral da sa\u00fade infantojuvenil: complementava a assist\u00eancia (oferecida desde 1919 pelo Hospital) e a educa\u00e7\u00e3o (oferecida desde 2003 pela Faculdades), refor\u00e7ando, assim, o engajamento do Complexo na causa da inf\u00e2ncia e da adolesc\u00eancia. Seria um instituto de pesquisa, sim, mas com preocupa\u00e7\u00e3o social \u2013 como devem ser todos os cientistas, segundo as s\u00e1bias palavras de uma das grandes personalidades da \u00e1rea, figura fundamental para a cria\u00e7\u00e3o do Escrit\u00f3rio de Inova\u00e7\u00e3o do Pequeno Pr\u00edncipe: o f\u00edsico-qu\u00edmico S\u00e9rgio Mascarenhas, que faleceu em 2021.<\/p><p>Quinze anos depois de criado, o Instituto registrou, mesmo com as adapta\u00e7\u00f5es exigidas pelos tempos pand\u00eamicos, um volume excepcional de produ\u00e7\u00e3o cient\u00edfica. Em 2021, os pesquisadores dobraram o n\u00famero de publica\u00e7\u00f5es em rela\u00e7\u00e3o \u00e0 m\u00e9dia dos quatro anos anteriores. Diversos trabalhos iniciados em 2020 \u2013 sobretudo para melhorar o diagn\u00f3stico, a caracteriza\u00e7\u00e3o e o tratamento da COVID-19 \u2013 foram intensificados. Entre eles, a cria\u00e7\u00e3o de um soro com anticorpos contra a doen\u00e7a. A relev\u00e2ncia de muitos estudos foi reconhecida em peri\u00f3dicos de n\u00edvel A1, o mais alto do Qualis Capes (sistema oficial brasileiro de classifica\u00e7\u00e3o da produ\u00e7\u00e3o cient\u00edfica), como a <em>Science Immunology, Nature Immunology, Cancer Research<\/em>, entre outros.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a2f0bd2 elementor-widget elementor-widget-text-editor\" data-id=\"a2f0bd2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Essas conquistas resultaram de algumas mudan\u00e7as de estrat\u00e9gia:<\/p><ul><li>Com os trabalhos cl\u00ednicos ainda afetados pelo distanciamento social, que dificulta o acompanhamento dos participantes, o Instituto enfatizou projetos que podiam ser conduzidos a dist\u00e2ncia.<\/li><li>Os pesquisadores se dedicaram \u00e0 an\u00e1lise de dados j\u00e1 obtidos, buscaram informa\u00e7\u00f5es em bases p\u00fablicas internacionais e produziram trabalhos de revis\u00f5es narrativas, sistem\u00e1ticas, meta-an\u00e1lises (an\u00e1lises estat\u00edsticas a partir dos resultados de m\u00faltiplos estudos cient\u00edficos) e mais complexos, do tipo big data <em>in silico<\/em> (an\u00e1lises gen\u00f4micas, prote\u00f4micas e transcript\u00f4micas).<\/li><li>As coopera\u00e7\u00f5es com institui\u00e7\u00f5es nacionais e estrangeiras foram refor\u00e7adas. Assim, o Instituto se beneficiou de achados obtidos pelos parceiros de pesquisa no Brasil e no exterior, principalmente em projetos relacionados \u00e0 COVID-19 e ao c\u00e2ncer pedi\u00e1trico.<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93f5b05 elementor-widget elementor-widget-spacer\" data-id=\"93f5b05\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-99e575a\" data-id=\"99e575a\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-522a990 elementor-widget elementor-widget-spacer\" data-id=\"522a990\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e7e5ba elementor-widget elementor-widget-text-editor\" data-id=\"6e7e5ba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>O trabalho presente dos cientistas \u00e9 que molda o futuro da assist\u00eancia em sa\u00fade.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0c992c elementor-widget elementor-widget-image\" data-id=\"f0c992c\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"768\" height=\"511\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-768x511.jpeg\" class=\"attachment-medium_large size-medium_large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-768x511.jpeg 768w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-300x200.jpeg 300w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-1024x681.jpeg 1024w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4-1536x1022.jpeg 1536w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/Sergio_Mascarenhas-4.jpeg 2000w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4502dbb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4502dbb\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5863c98\" data-id=\"5863c98\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-460e6db elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"460e6db\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6664662\" data-id=\"6664662\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e265928 elementor-widget elementor-widget-text-editor\" data-id=\"e265928\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h5 style=\"color: #006c88;\"><strong>Maturidade aos 15 anos<\/strong><\/h5><p>Em tempos normais, seria num audit\u00f3rio, talvez com semin\u00e1rios seguidos de visita aos laborat\u00f3rios. Mas os 15 anos de inaugura\u00e7\u00e3o do Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe foram completados em meio a um dos piores meses da COVID-19, em abril de 2021. A comemora\u00e7\u00e3o, ent\u00e3o, teve de ser on-line: uma live com cerca de cem participantes relembrou os principais projetos em andamento, ressaltou a import\u00e2ncia das pesquisas desenvolvidas e destacou a forma\u00e7\u00e3o acad\u00eamica oferecida.<\/p><p>Mesmo isolados, cada um de sua tela, os profissionais emocionaram-se ao recordar as conquistas mais relevantes e os companheiros que ajudaram a construir o come\u00e7o dessa jornada em prol da inf\u00e2ncia e da adolesc\u00eancia.<\/p><p>Em seus primeiros 15 anos, o Instituto de Pesquisa formou quase 130 mestres e doutores, publicou mais de 350 artigos cient\u00edficos e produziu conhecimentos que j\u00e1 beneficiaram milhares de crian\u00e7as: um exame acrescentado ao teste principal do pezinho (<em>TP53<\/em> p.R337H) para descobrir a segunda muta\u00e7\u00e3o gen\u00e9tica heredit\u00e1ria (<em>XAF1<\/em> p.E134*) associada \u00e0 predisposi\u00e7\u00e3o para o desenvolvimento de um tipo de c\u00e2ncer infantil que tem a maior incid\u00eancia mundial no Paran\u00e1 (tumor de c\u00f3rtex adrenal), o quinto maior estudo mundial para detec\u00e7\u00e3o de imunodefici\u00eancias prim\u00e1rias (erros inatos da imunidade), estudos para melhorar a detec\u00e7\u00e3o de transtornos de d\u00e9ficit de aten\u00e7\u00e3o e hiperatividade \u2013 e tantos outros avan\u00e7os.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65dd7d0 elementor-widget elementor-widget-image-carousel\" data-id=\"65dd7d0\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;1&quot;,&quot;navigation&quot;:&quot;none&quot;,&quot;effect&quot;:&quot;fade&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-widget-image-carousel .swiper-container{position:static}.elementor-widget-image-carousel .swiper-container .swiper-slide figure{line-height:inherit}.elementor-widget-image-carousel .swiper-slide{text-align:center}.elementor-image-carousel-wrapper:not(.swiper-container-initialized) .swiper-slide{max-width:calc(100% \/ var(--e-image-carousel-slides-to-show, 3))}<\/style>\t\t<div class=\"elementor-image-carousel-wrapper swiper-container\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper swiper-image-stretch\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/15_anos_IPP_GERAL_1-1024x576.jpeg\" alt=\"15_anos_IPP_GERAL_1\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/15_anos_IPP_GERAL_2-1024x576.jpeg\" alt=\"15_anos_IPP_GERAL_2\" \/><\/figure><\/div><div class=\"swiper-slide\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/15_anos_IPP_GERAL_3-1024x576.jpeg\" alt=\"15_anos_IPP_GERAL_3\" \/><\/figure><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-be174d8 elementor-widget elementor-widget-spacer\" data-id=\"be174d8\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-571bd70\" data-id=\"571bd70\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5586a86 elementor-testimonial--align-left elementor-testimonial--skin-default elementor-testimonial--layout-image_inline elementor-arrows-yes elementor-pagination-type-bullets elementor-widget elementor-widget-testimonial-carousel\" data-id=\"5586a86\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:250,&quot;sticky_effects_offset&quot;:250,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;show_arrows&quot;:&quot;yes&quot;,&quot;pagination&quot;:&quot;bullets&quot;,&quot;speed&quot;:500,&quot;autoplay&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;loop&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;space_between&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;space_between_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;space_between_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]}}\" data-widget_type=\"testimonial-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/plugins\/elementor-pro\/assets\/css\/widget-carousel.min.css\">\t\t<div class=\"elementor-swiper\">\n\t\t\t<div class=\"elementor-main-swiper swiper-container\">\n\t\t\t\t<div class=\"swiper-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cEu tenho que dar os parab\u00e9ns ao Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe pelos 15 anos de dedica\u00e7\u00e3o \u00e0 ci\u00eancia e por ajudar a salvar vidas.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Pel\u00e9<\/span><span class=\"elementor-testimonial__title\">padrinho do Instituto de Pesquisa<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cAqui, eu pude ver o cuidado, a inquieta\u00e7\u00e3o, o n\u00e3o se conformar e o querer de todos em fazer mais pelas crian\u00e7as, fam\u00edlias, colaboradores e para a nossa comunidade.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Ety Cristina Forte Carneiro<\/span><span class=\"elementor-testimonial__title\">diretora-geral do Instituto de Pesquisa<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cEm 1969, Pel\u00e9 disse que o povo brasileiro n\u00e3o poderia se esquecer das crian\u00e7as. E \u00e9 isso que estamos fazendo desde 2006.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Bonald Cavalcante de Figueiredo<\/span><span class=\"elementor-testimonial__title\">diretor-cient\u00edfico do Instituto<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cFazer ci\u00eancia \u00e9 abastecer-se da energia que pulsa a cada nova descoberta e a cada vida que temos o potencial de impactar com ela.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Carolina Prando<\/span><span class=\"elementor-testimonial__title\">diretora de Medicina Translacional do Instituto<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cGostaria de citar a frase de Saint-Exup\u00e9ry: \u2018Aqueles que passam por n\u00f3s n\u00e3o v\u00e3o s\u00f3s, n\u00e3o nos deixam s\u00f3s. Deixam um pouco de si, levam um pouco de n\u00f3s\u2019.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Mara L\u00facia Cordeiro<\/span><span class=\"elementor-testimonial__title\">diretora de Rela\u00e7\u00f5es Institucionais do Instituto, em lembran\u00e7a ao m\u00e9dico Nilson Santos, um dos criadores da unidade do Complexo Pequeno Pr\u00edncipe<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-testimonial\">\n\t\t\t\t\t\t\t<div class=\"elementor-testimonial__content\">\n\t\t\t\t\t<div class=\"elementor-testimonial__text\">\n\t\t\t\t\t\t\u201cGostaria de parabenizar todos, na certeza de que, juntos, constru\u00edmos e construiremos uma ci\u00eancia comprometida com a dignidade humana, a sa\u00fade planet\u00e1ria e o amor \u00e0 vida.\u201d\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-testimonial__footer\">\n\t\t\t\t\t\t\t\t<cite class=\"elementor-testimonial__cite\"><span class=\"elementor-testimonial__name\">Patricia Forte Rauli<\/span><span class=\"elementor-testimonial__title\">diretora-geral da Faculdades Pequeno Pr\u00edncipe<\/span><\/cite>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-left\"><\/i>\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Anterior<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-chevron-right\"><\/i>\t\t\t\t\t\t\t<span class=\"elementor-screen-only\">Pr\u00f3ximo<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-789d77f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"789d77f\" data-element_type=\"section\" id=\"6-2\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-405e3b6\" data-id=\"405e3b6\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f35a799 elementor-widget elementor-widget-spacer\" data-id=\"f35a799\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dd496cd elementor-widget elementor-widget-heading\" data-id=\"dd496cd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xxl\">As pesquisas \nem destaque<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a6f2b6 elementor-widget elementor-widget-spacer\" data-id=\"3a6f2b6\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2378247 elementor-widget elementor-widget-heading\" data-id=\"2378247\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-large\">A COVID-19 em an\u00e1lise\n<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0483ac5 elementor-widget elementor-widget-text-editor\" data-id=\"0483ac5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>O conhecimento acumulado sobre a COVID-19 no primeiro ano da pandemia foi fundamental para melhorar o tratamento dos pacientes infectados com o coronav\u00edrus e combater a dissemina\u00e7\u00e3o desse v\u00edrus. No entanto, muitos aspectos do SARS-CoV-2 precisam continuar a ser estudados. O Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe se soma ao esfor\u00e7o da comunidade cient\u00edfica mundial principalmente para:<\/p><ol><li>Compreender em detalhes o comportamento de diferentes variantes do SARS-CoV-2, inclusive em pessoas com outras doen\u00e7as.<\/li><li>Investigar consequ\u00eancias das terapias em uso.<\/li><li>Desenvolver meios de evitar casos graves ap\u00f3s o cont\u00e1gio.<\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64758f1 elementor-widget elementor-widget-spacer\" data-id=\"64758f1\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4c6b9b2\" data-id=\"4c6b9b2\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-abfe1f2 elementor-widget elementor-widget-spacer\" data-id=\"abfe1f2\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe411de elementor-widget elementor-widget-image\" data-id=\"fe411de\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/Pesquisa_COVID_Dra_Carol_Prando-5-psfegmh6siwq35rv4maxiikyx4gzheex66m6q6vi9w.jpeg\" title=\"Pesquisa_COVID_Dra_Carol_Prando (5)\" alt=\"Pesquisa_COVID_Dra_Carol_Prando (5)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b2c088 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1b2c088\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-01bad94\" data-id=\"01bad94\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f6b75a8 elementor-widget elementor-widget-spacer\" data-id=\"f6b75a8\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6891db8 elementor-widget elementor-widget-heading\" data-id=\"6891db8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-large\">O que esses estudos buscam?\n<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38ffe98 elementor-widget elementor-widget-toggle\" data-id=\"38ffe98\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.7.0 - 08-08-2022 *\/\n.elementor-toggle{text-align:left}.elementor-toggle .elementor-tab-title{font-weight:700;line-height:1;margin:0;padding:15px;border-bottom:1px solid #d4d4d4;cursor:pointer;outline:none}.elementor-toggle .elementor-tab-title .elementor-toggle-icon{display:inline-block;width:1em}.elementor-toggle .elementor-tab-title .elementor-toggle-icon svg{-webkit-margin-start:-5px;margin-inline-start:-5px;width:1em;height:1em}.elementor-toggle .elementor-tab-title .elementor-toggle-icon.elementor-toggle-icon-right{float:right;text-align:right}.elementor-toggle .elementor-tab-title .elementor-toggle-icon.elementor-toggle-icon-left{float:left;text-align:left}.elementor-toggle .elementor-tab-title .elementor-toggle-icon .elementor-toggle-icon-closed{display:block}.elementor-toggle .elementor-tab-title .elementor-toggle-icon .elementor-toggle-icon-opened{display:none}.elementor-toggle .elementor-tab-title.elementor-active{border-bottom:none}.elementor-toggle .elementor-tab-title.elementor-active .elementor-toggle-icon-closed{display:none}.elementor-toggle .elementor-tab-title.elementor-active .elementor-toggle-icon-opened{display:block}.elementor-toggle .elementor-tab-content{padding:15px;border-bottom:1px solid #d4d4d4;display:none}@media (max-width:767px){.elementor-toggle .elementor-tab-title{padding:12px}.elementor-toggle .elementor-tab-content{padding:12px 10px}}.e-container>.elementor-widget-toggle{width:var(--container-widget-width,100%)}<\/style>\t\t<div class=\"elementor-toggle\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5971\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-5971\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Investigar a rela\u00e7\u00e3o entre altera\u00e7\u00f5es gen\u00e9ticas e o coronav\u00edrus<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5971\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5971\"><p>Um estudo analisa como a heran\u00e7a gen\u00e9tica e os fatores imunol\u00f3gicos est\u00e3o associados \u00e0 infec\u00e7\u00e3o, o que pode ajudar a definir protocolos e novas terapias. O projeto faz parte do <a href=\"https:\/\/www.covidhge.com\/\" target=\"_blank\" rel=\"noopener\">COVID Human Genetic Effort<\/a>, uma iniciativa com participa\u00e7\u00e3o de cientistas do mundo todo. No Brasil, \u00e9 coordenado por uma pesquisadora do Instituto.<\/p><p>Outro grupo pesquisa a s\u00edndrome de ativa\u00e7\u00e3o macrof\u00e1gica, doen\u00e7a gen\u00e9tica rara que afeta o sistema imunol\u00f3gico e provoca a prolifera\u00e7\u00e3o excessiva de c\u00e9lulas de defesa, chamadas de macr\u00f3fagos. Em parceria com a Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR), os cientistas analisaram tecidos pulmonares de pessoas que morreram em consequ\u00eancia da COVID-19 e conclu\u00edram que a altera\u00e7\u00e3o gen\u00e9tica pode ser um fator de risco para infectados pelo coronav\u00edrus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5972\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"tab\" aria-controls=\"elementor-tab-content-5972\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Viabilizar novos tratamentos da s\u00edndrome metab\u00f3lica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5972\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5972\"><p>A s\u00edndrome metab\u00f3lica \u2013 uma reuni\u00e3o de fatores de risco envolvendo problemas cardiovasculares, obesidade e resist\u00eancia \u00e0 insulina \u2013 aumenta o risco de doen\u00e7as card\u00edacas, derrames e diabetes. Tamb\u00e9m eleva as chances de morte em infectados pelo SARS-CoV-2. Um projeto do Instituto de Pesquisa pretende elucidar os mecanismos da s\u00edndrome para identificar novas oportunidades de tratamento dessa condi\u00e7\u00e3o.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5973\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"tab\" aria-controls=\"elementor-tab-content-5973\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Identificar a fun\u00e7\u00e3o dos miRNAs na intera\u00e7\u00e3o viral<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5973\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5973\"><p>Pequenos tipos de RNA (mol\u00e9culas que fazem a s\u00edntese de prote\u00ednas), os miRNAs t\u00eam papel importante na regula\u00e7\u00e3o da resposta ao v\u00edrus. Alertam o sistema imunol\u00f3gico, mas podem tamb\u00e9m levar a uma rea\u00e7\u00e3o exagerada que provoca inflama\u00e7\u00f5es e favorece o SARS-CoV-2. A revis\u00e3o sistem\u00e1tica de estudos sobre o tema, feita em conjunto com pesquisadores da PUCPR, mostrou que a an\u00e1lise dos miRNAs ajuda a definir grupos de risco e que a mol\u00e9cula pode ser alvo de futuros tratamentos contra a COVID-19.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5974\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"tab\" aria-controls=\"elementor-tab-content-5974\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Medir a radia\u00e7\u00e3o em exames de crian\u00e7as com suspeita de COVID-19<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5974\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5974\"><p>Antes mesmo de terem o diagn\u00f3stico de COVID-19 confirmado, pequenos pacientes com sintomas que demandam mais aten\u00e7\u00e3o s\u00e3o submetidos com frequ\u00eancia a uma tomografia computadorizada de t\u00f3rax. O exame ajuda a analisar melhor o quadro de sa\u00fade, mas exp\u00f5e as crian\u00e7as a doses muito altas de radia\u00e7\u00e3o \u2013 o que, em alguns casos, pode provocar c\u00e2ncer. O Instituto come\u00e7ou a medir os valores dessas doses para compar\u00e1-las a n\u00edveis estabelecidos nacional e internacionalmente, al\u00e9m de descobrir se tomografias feitas sem seda\u00e7\u00e3o elevam a exposi\u00e7\u00e3o \u00e0 radia\u00e7\u00e3o.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5975\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"tab\" aria-controls=\"elementor-tab-content-5975\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Tra\u00e7ar como a COVID-19 evolui em pacientes com erros inatos da imunidade<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5975\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5975\"><p>Erros inatos da imunidade s\u00e3o um grupo de mais de 400 doen\u00e7as gen\u00e9ticas raras que afetam o funcionamento do sistema imune e podem levar a infec\u00e7\u00f5es graves. O estudo com 121 participantes, desenvolvido em parceria com universidades do Brasil e do exterior, concluiu que as enfermidades n\u00e3o foram um fator determinante para maior gravidade da COVID-19, exceto nos pacientes que apresentavam comorbidades.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5976\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"tab\" aria-controls=\"elementor-tab-content-5976\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Conhecer a evolu\u00e7\u00e3o cl\u00ednica e laboratorial da COVID-19 em crian\u00e7as e adolescentes <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5976\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5976\"><p>No in\u00edcio da pandemia, a faixa et\u00e1ria pedi\u00e1trica parecia ser menos afetada pelo coronav\u00edrus. Essa percep\u00e7\u00e3o mudou com o tempo, por isso \u00e9 relevante coletar e processar todas as informa\u00e7\u00f5es dispon\u00edveis sobre as manifesta\u00e7\u00f5es cl\u00ednicas e a evolu\u00e7\u00e3o da doen\u00e7a em crian\u00e7as e adolescentes.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5977\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"tab\" aria-controls=\"elementor-tab-content-5977\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Determinar efeitos da infec\u00e7\u00e3o ao longo do primeiro ano p\u00f3s-COVID-19 <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5977\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5977\"><p>Al\u00e9m dos sintomas que acompanham a infec\u00e7\u00e3o aguda, sabe-se hoje que o coronav\u00edrus tamb\u00e9m tem efeitos de longo prazo. O projeto avalia os casos de profissionais de sa\u00fade infectados pelo SARS-CoV-2 e faz o levantamento de poss\u00edveis sequelas um ano ap\u00f3s o cont\u00e1gio.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5978\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"tab\" aria-controls=\"elementor-tab-content-5978\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Identificar indicadores de agravamento da COVID-19<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5978\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5978\"><p>Uma meta-an\u00e1lise feita em parceria com outras institui\u00e7\u00f5es brasileiras revisou e comparou os resultados de 12 estudos sobre biomarcadores \u2013 sinais biol\u00f3gicos que indicam altera\u00e7\u00f5es no organismo \u2013 associados ao sistema imunol\u00f3gico e relacionados a quadros inflamat\u00f3rios. O estudo mostrou que a baixa contagem de linf\u00f3citos est\u00e1 ligada a quadros graves de COVID-19, o que significa que \u00e9 poss\u00edvel identificar pacientes com possibilidade de evolu\u00e7\u00e3o cr\u00edtica por meio de um hemograma.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5979\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"tab\" aria-controls=\"elementor-tab-content-5979\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Desenvolver parte de um pulm\u00e3o com impressora 3D para testar medicamentos<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5979\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-5979\"><p>O projeto, realizado em parceria com a Universidade Tecnol\u00f3gica Federal do Paran\u00e1 (UTFPR), inaugura a bioimpress\u00e3o no Instituto. Ele vai reproduzir in vitro um alv\u00e9olo (unidade funcional dos pulm\u00f5es) para ser usado em testes de drogas de a\u00e7\u00e3o pulmonar, inclusive contra a COVID-19. A bioimpress\u00e3o usa como mat\u00e9ria-prima o biogel, subst\u00e2ncia formada por prote\u00edna e \u00e1gua misturada a nutrientes. O composto permite o crescimento de c\u00e9lulas, dando origem a tecidos humanos. No futuro, os cientistas esperam conseguir imprimir \u00f3rg\u00e3os inteiros. <\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-59710\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"tab\" aria-controls=\"elementor-tab-content-59710\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Avaliar se drogas no mercado reduzem a carga viral em infectados<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-59710\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-59710\"><p>Um ensaio cl\u00ednico randomizado come\u00e7ou a comparar o desempenho de dois medicamentos existentes no mercado, a claritromicina e a ivermectina, para verificar se s\u00e3o capazes de reduzir a carga do SARS-CoV-2 em pacientes em estado grave. Atualmente, as drogas s\u00e3o recomendadas primordialmente como antimicrobianos e antiparasit\u00e1rios.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b4e5fe elementor-widget elementor-widget-spacer\" data-id=\"5b4e5fe\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-42f94a4\" data-id=\"42f94a4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e7517e elementor-widget elementor-widget-text-editor\" data-id=\"2e7517e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Os pesquisadores do Instituto somaram esfor\u00e7os com a comunidade cient\u00edfica mundial para avan\u00e7ar no conhecimento sobre o coronav\u00edrus.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-015377c elementor-widget elementor-widget-image\" data-id=\"015377c\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/covid-virus-3d-modeling_freepik-przr9rhn4w5ifo522p6gwt1g2koh2cmeyxui6cm2x0.jpeg\" title=\"covid-virus-3d-modeling_freepik\" alt=\"covid-virus-3d-modeling_freepik\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7bd5574 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7bd5574\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f85fa32\" data-id=\"f85fa32\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f216748 elementor-widget elementor-widget-spacer\" data-id=\"f216748\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f654370\" data-id=\"f654370\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f672208 elementor-widget elementor-widget-spacer\" data-id=\"f672208\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5b00e46 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5b00e46\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-21f1e7b\" data-id=\"21f1e7b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64286e3 elementor-widget elementor-widget-spacer\" data-id=\"64286e3\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7eac687 elementor-widget elementor-widget-heading\" data-id=\"7eac687\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">Anticorpos para neutralizar o coronav\u00edrus\n<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a43e8a elementor-widget elementor-widget-text-editor\" data-id=\"3a43e8a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Um dos projetos do Instituto de Pesquisa na \u00e1rea da COVID-19 \u00e9 o desenvolvimento de anticorpos contra o coronav\u00edrus a partir do plasma de cavalos. Iniciado em 2020, o estudo concluiu suas fases preliminares em 2021.<\/p><p>Ap\u00f3s a produ\u00e7\u00e3o de um soro pelo Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe e o Centro de Produ\u00e7\u00e3o e Pesquisa de Imunobiol\u00f3gicos <strong>(CPPI, que faz parte da Funda\u00e7\u00e3o Estatal de Aten\u00e7\u00e3o \u00e0 Sa\u00fade, a Funeas, \u00f3rg\u00e3o da Secretaria de Estado da Sa\u00fade do Paran\u00e1)<\/strong>, o soro bruto de cavalo segue para extra\u00e7\u00e3o de anticorpos na Funda\u00e7\u00e3o Ezequiel Dias (Funed), em Minas Gerais, para depois confirmar sua efici\u00eancia no bloqueio do SARS-CoV-2 em camundongos modificados geneticamente para contrair a COVID-19. A an\u00e1lise da efici\u00eancia e da seguran\u00e7a do soro ser\u00e1 feita em laborat\u00f3rios do Centro de Produ\u00e7\u00e3o e Pesquisa de Imunobiol\u00f3gicos e da Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) no Paran\u00e1.<\/p><p>O tratamento foi idealizado por pesquisadores do Pequeno Pr\u00edncipe com base no conceito de imunidade passiva, em que o paciente recebe anticorpos prontos em vez de produzi-los no corpo. \u00c9 indicado para pessoas sem imunidade contra o coronav\u00edrus \u2013 tanto n\u00e3o vacinadas quanto as imunizadas que foram incapazes de produzir anticorpos.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-314cdcd elementor-widget elementor-widget-spacer\" data-id=\"314cdcd\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8823fe4\" data-id=\"8823fe4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e23244f elementor-widget elementor-widget-image\" data-id=\"e23244f\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/Dr_Bonald-6-pryhu2oa9p0n002jcnw6ykf226s8ft1s312ju1v6mc.jpg\" title=\"Dr_Bonald (6)\" alt=\"Dr_Bonald (6)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0f35cb3 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0f35cb3\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5569397\" data-id=\"5569397\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4de2f22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4de2f22\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-7c97b0c\" data-id=\"7c97b0c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-08c7a67 elementor-widget elementor-widget-text-editor\" data-id=\"08c7a67\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h5 style=\"color: #006c88;\"><strong>As fases do projeto<\/strong><\/h5>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5f2c9c elementor-widget elementor-widget-image\" data-id=\"d5f2c9c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"instituto_fases_projeto\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTI4MiwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA3XC9pbnN0aXR1dG9fZmFzZXNfcHJvamV0by5qcGcifQ%3D%3D\">\n\t\t\t\t\t\t\t<img width=\"783\" height=\"1024\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto-783x1024.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto-783x1024.jpg 783w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto-229x300.jpg 229w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto-768x1005.jpg 768w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_fases_projeto.jpg 862w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-f2278ae elementor-widget elementor-widget-spacer\" data-id=\"f2278ae\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-936505d\" data-id=\"936505d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e02b74d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e02b74d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a5a56ae\" data-id=\"a5a56ae\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-152f8aa elementor-widget elementor-widget-spacer\" data-id=\"152f8aa\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8bbd947 elementor-widget elementor-widget-heading\" data-id=\"8bbd947\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">Causas gen\u00e9ticas e imunol\u00f3gicas das formas graves de COVID-19<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce8560 elementor-widget elementor-widget-text-editor\" data-id=\"9ce8560\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Duas descobertas publicadas em 2021 na revista <em>Science<\/em> nasceram de pesquisas do cons\u00f3rcio <em>COVID Human Genetic Effort<\/em>, um projeto internacional que abrange centenas de hospitais em todo o mundo e que, no Brasil, tem um grupo liderado pelo Instituto de Pesquisa. Os artigos mostraram que mais de 10% das pessoas jovens e saud\u00e1veis que desenvolvem formas graves de COVID-19 produzem anticorpos que atacam n\u00e3o o v\u00edrus, mas o pr\u00f3prio sistema imunol\u00f3gico (autoanticorpo). Outros 3,5%, pelo menos, carregam um tipo espec\u00edfico de muta\u00e7\u00e3o gen\u00e9tica que afeta a resposta imunol\u00f3gica.<\/p><p>Nos dois casos, os pacientes n\u00e3o disp\u00f5em adequadamente de interferon tipo I, um grupo de 17 prote\u00ednas fundamentais para proteger o organismo. Isso ocorre ou porque as prote\u00ednas foram neutralizadas pelos autoanticorpos ou porque n\u00e3o foram produzidas em quantidades suficientes devido a um gene defeituoso. Tais situa\u00e7\u00f5es ajudam a explicar a raz\u00e3o de algumas pessoas desenvolverem formas mais graves de COVID-19 do que outras da mesma faixa et\u00e1ria. A boa not\u00edcia \u00e9 que os pacientes com essas caracter\u00edsticas podem ser tratados com medica\u00e7\u00f5es j\u00e1 dispon\u00edveis no mercado, reduzindo o risco de morte por COVID-19.<\/p><p>Ao se debru\u00e7ar sobre os pacientes graves, o estudo detectou que 10% deles (a grande maioria homem, 95%) desenvolviam os autoanticorpos no in\u00edcio da infec\u00e7\u00e3o. O achado tem impacto nos tratamentos com plasma de humanos convalescentes: se o doador tiver autoanticorpos, seu plasma n\u00e3o poder\u00e1 ser usado no tratamento de outras pessoas.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-03237a3\" data-id=\"03237a3\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d74a4d7 elementor-widget elementor-widget-spacer\" data-id=\"d74a4d7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ad3a23 elementor-widget elementor-widget-image\" data-id=\"5ad3a23\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.covidhge.com\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/logo_CHGE-przqj8hm97srmdbj51od7qg3khb1n5d65xalitmnzi.png\" title=\"logo_CHGE\" alt=\"logo_CHGE\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7267e elementor-widget elementor-widget-spacer\" data-id=\"ad7267e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ee867de elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ee867de\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1a6f00e\" data-id=\"1a6f00e\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fb50f7 elementor-widget elementor-widget-spacer\" data-id=\"4fb50f7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f643494 elementor-widget elementor-widget-heading\" data-id=\"f643494\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">Expans\u00e3o do Big Data\n<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a6fd6a3 elementor-widget elementor-widget-text-editor\" data-id=\"a6fd6a3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Criado em 2020, o grupo de pesquisa Big Data ganhou novos integrantes. Eles ajudam a equipe em trabalhos que usam computadores de alta capacidade de processamento para analisar informa\u00e7\u00f5es de bancos de dados internacionais de acesso livre em diferentes \u00e1reas.<\/p><p>Em 2021, o grupo produziu artigos sobre o efeito do tabagismo em m\u00e1s-forma\u00e7\u00f5es cong\u00eanitas; a incid\u00eancia de c\u00e2ncer de bexiga e de pulm\u00e3o no continente americano; e a imunologia do tumor de c\u00f3rtex adrenal (a parte externa das gl\u00e2ndulas suprarrenais). Os resultados desse \u00faltimo estudo sustentam um novo projeto para desenvolver uma vacina terap\u00eautica contra o c\u00e2ncer de c\u00f3rtex adrenal. Trata-se de uma pesquisa de alta complexidade, realizada em c\u00e9lulas vivas armazenadas no Biobanco do Pequeno Pr\u00edncipe, onde s\u00e3o guardados tecidos humanos destinados a estudos internos e doa\u00e7\u00f5es.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f683f94 elementor-widget elementor-widget-spacer\" data-id=\"f683f94\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2b8b1af elementor-hidden-mobile\" data-id=\"2b8b1af\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-115db4b elementor-widget elementor-widget-spacer\" data-id=\"115db4b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dfec57b elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"dfec57b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8f8338b\" data-id=\"8f8338b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aceabfc elementor-widget elementor-widget-spacer\" data-id=\"aceabfc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-30b6792\" data-id=\"30b6792\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cd3402a elementor-widget elementor-widget-spacer\" data-id=\"cd3402a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ad87f26 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ad87f26\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3a9ee96\" data-id=\"3a9ee96\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-733981c elementor-widget elementor-widget-spacer\" data-id=\"733981c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b70f806 elementor-widget elementor-widget-heading\" data-id=\"b70f806\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xl\">Projetos iniciados em 2021<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24abf0c elementor-widget elementor-widget-text-editor\" data-id=\"24abf0c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Nas suas sete linhas de pesquisa, o Instituto conta com 96 projetos em desenvolvimento. A seguir, alguns destaques.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e79f588 elementor-widget elementor-widget-toggle\" data-id=\"e79f588\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2421\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-2421\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Doen\u00e7as complexas e oncogen\u00e9tica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2421\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2421\"><p><strong>Tema do projeto:<\/strong> an\u00e1lise gen\u00e9tica de tecidos com sarcoma de Ewing<br \/><strong>Objetivo:<\/strong> identificar altera\u00e7\u00f5es de genes em pacientes que desenvolvem o sarcoma de Ewing, um tipo de c\u00e2ncer que ocorre no interior ou em torno dos ossos de crian\u00e7as e jovens adultos.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2422\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"tab\" aria-controls=\"elementor-tab-content-2422\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Terapia celular e farmacol\u00f3gica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2422\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2422\"><p><strong>Tema do projeto:<\/strong> terapia de microRNAs de c\u00e9lulas precursoras neuronais no tratamento da doen\u00e7a de Parkinson<br \/><strong>Objetivo:<\/strong> como parte do programa de Plataformas Inovadoras em Terapias Avan\u00e7adas, do Minist\u00e9rio da Sa\u00fade, o projeto para o desenvolvimento de novos tratamentos para a doen\u00e7a de Parkinson, que recebeu recursos em 2020, come\u00e7ou a fazer seus experimentos em 2021. O estudo busca desenvolver um nanomedicamento biol\u00f3gico seguro, a partir de produtos derivados das c\u00e9lulas precursoras neuronais obtidas da diferencia\u00e7\u00e3o de c\u00e9lulas-tronco do cord\u00e3o umbilical humano.<\/p><p><strong>Tema do projeto:<\/strong> otimiza\u00e7\u00e3o da obten\u00e7\u00e3o de precursoras neuronais e seus derivados em material h\u00edbrido \u2013 biomaterial e grafeno<br \/><strong>Objetivo:<\/strong> otimizar a obten\u00e7\u00e3o de precursoras neuronais e seus derivados em material h\u00edbrido (membrana NFBX de biopol\u00edmero incorporada com nanopart\u00edculas de grafeno) para a maior produ\u00e7\u00e3o e expans\u00e3o celular no desenvolvimento de novas terapias para as doen\u00e7as neurodegenerativas e do neurodesenvolvimento. As c\u00e9lulas percebem o microambiente ao seu redor por meio da sinaliza\u00e7\u00e3o qu\u00edmica ou pela interpreta\u00e7\u00e3o de for\u00e7as f\u00edsicas, que podem ser geradas tanto de forma interna como de forma externa em resposta a propriedades f\u00edsicas como rigidez ou elasticidade do substrato, contratilidade celular ou, ainda, pela for\u00e7a gerada por c\u00e9lulas vizinhas. Essa capacidade das c\u00e9lulas de transformar est\u00edmulos mec\u00e2nicos em respostas qu\u00edmicas \u00e9 chamada de mecanotransdu\u00e7\u00e3o e \u00e9 essencial para modular o comportamento celular, influenciando o destino das c\u00e9lulas em rela\u00e7\u00e3o \u00e0 prolifera\u00e7\u00e3o, sobreviv\u00eancia, diferencia\u00e7\u00e3o e, at\u00e9 mesmo, nos processos de regenera\u00e7\u00e3o de tecidos e reparo de les\u00f5es. Por outro lado, o grafeno possui uma estrutura bidimensional, alta \u00e1rea de superf\u00edcie, alta condutividade el\u00e9trica, estabilidade qu\u00edmica e propriedades flexivas. Essas caracter\u00edsticas permitem que o grafeno seja capaz de imobilizar subst\u00e2ncias como metais, drogas, sondas fluorescentes e c\u00e9lulas, atraindo o interesse na medicina regenerativa. Estudos recentes demonstram que o grafeno, ou materiais \u00e0 base de grafeno, promovem ades\u00e3o, prolifera\u00e7\u00e3o e diferencia\u00e7\u00e3o de v\u00e1rios tipos de c\u00e9lulas, incluindo as c\u00e9lulas-tronco.<\/p><p><strong>Tema do projeto:<\/strong> extra\u00e7\u00e3o do composto betaglucana de cogumelos medicinais<br \/><strong>Objetivo:<\/strong> estudar meios de baixo custo para extrair a betaglucana, presente em alguns tipos de cogumelo. Ela ativa o sistema imunol\u00f3gico e tem a\u00e7\u00e3o direta no tratamento da mucosite, inflama\u00e7\u00e3o da parte interna da boca e da garganta que pode acometer pacientes em tratamentos quimioter\u00e1picos.<\/p><p><strong>Tema do projeto:<\/strong> efeitos dos \u00e1cidos k\u00f3jico e glic\u00f3lico na produ\u00e7\u00e3o de melanina<br \/><strong>Objetivo:<\/strong> avaliar efeitos desses dois \u00e1cidos em c\u00e9lulas produtoras da melanina (prote\u00edna que determina a cor da pele), verificar se t\u00eam potencial de diminuir essa produ\u00e7\u00e3o e, assim, serem usados em tratamentos contra o melasma (hiperpigmenta\u00e7\u00e3o que causa manchas escuras na pele).<\/p><p><strong>Tema do projeto:<\/strong> transplante de medula \u00f3ssea em crian\u00e7as com fal\u00eancias medulares<br \/><strong>Objetivo:<\/strong> avaliar o perfil de pacientes com at\u00e9 5 anos de idade submetidos a transplante de c\u00e9lulas-tronco hematopoi\u00e9ticas de 1992 a 2020 em tr\u00eas institui\u00e7\u00f5es brasileiras, mostrar os resultados de sobrevida e descrever complica\u00e7\u00f5es precoces ou tardias ap\u00f3s a cirurgia.<\/p><p><strong>Tema do projeto:<\/strong> transplante de c\u00e9lulas-tronco em pacientes com erros inatos do metabolismo<br \/><strong>Objetivo:<\/strong> avaliar a sobrevida e as poss\u00edveis complica\u00e7\u00f5es ap\u00f3s o transplante de medula \u00f3ssea em crian\u00e7as com erros inatos do metabolismo. Essa condi\u00e7\u00e3o gen\u00e9tica prejudica o funcionamento correto da s\u00edntese de prote\u00ednas e pode causar desde v\u00f4mitos e infec\u00e7\u00f5es frequentes a doen\u00e7as g\u00e1stricas e problemas de crescimento. In\u00e9dita no Brasil, a an\u00e1lise se concentra em transplantados em seis hospitais pedi\u00e1tricos do pa\u00eds, entre 1988 e 2020.<\/p><p><strong>Tema do projeto:<\/strong> reincid\u00eancia de leucemias agudas ap\u00f3s transplante<br \/><strong>Objetivo:<\/strong> analisar o reaparecimento da doen\u00e7a e fatores de risco em pacientes com menos de 18 anos de idade que fizeram transplante de c\u00e9lulas-tronco hematopoi\u00e9ticas com doador. O foco do levantamento s\u00e3o crian\u00e7as e adolescentes submetidos ao procedimento entre 2010 e 2019 em tr\u00eas centros pedi\u00e1tricos brasileiros.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2423\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"tab\" aria-controls=\"elementor-tab-content-2423\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Neuroci\u00eancias<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2423\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2423\"><p><strong>Tema do projeto:<\/strong> efeitos do merc\u00fario t\u00f3xico na forma\u00e7\u00e3o de neur\u00f4nios<br \/><strong>Objetivo:<\/strong> analisar os efeitos de um tipo t\u00f3xico de merc\u00fario no crescimento e na diferencia\u00e7\u00e3o de neur\u00f4nios obtidos a partir de c\u00e9lulas-tronco, em busca de uma explica\u00e7\u00e3o para a doen\u00e7a de Parkinson.<\/p><p><strong>Tema do projeto:<\/strong> perfis neurol\u00f3gicos e gen\u00e9ticos de pacientes com mucopolissacaridose III no Brasil<br \/><strong>Objetivo:<\/strong> estudar o impacto da mucopolissacaridose tipo III, tamb\u00e9m chamada de s\u00edndrome de Sanfilippo, no c\u00e9rebro e no comportamento de crian\u00e7as e adolescentes.<\/p><p><strong>Tema do projeto:<\/strong> compara\u00e7\u00e3o do diagn\u00f3stico do transtorno do espectro autista (TEA) em pa\u00edses desenvolvidos e em desenvolvimento<br \/><strong>Objetivo:<\/strong> a pesquisa avalia os m\u00e9todos, os primeiros sintomas do TEA e quem os observa (pediatras, pais ou professores) em crian\u00e7as, e compara os resultados de pa\u00edses desenvolvidos (com renda m\u00e9dia alta) com os de pa\u00edses em desenvolvimento (com renda baixa). Essa pesquisa pode indicar quais os sintomas mais importantes e quem os observa primeiro, contribuindo para ajudar no tratamento precoce.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2424\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"tab\" aria-controls=\"elementor-tab-content-2424\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Imaginologia, prote\u00e7\u00e3o radiol\u00f3gica e radioterapia<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2424\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2424\"><p><strong>Tema do projeto:<\/strong> qualidade de imagem digital e t\u00e9cnicas radiogr\u00e1ficas em pediatria<br \/><strong>Objetivo:<\/strong> quantificar doses de radia\u00e7\u00e3o em crian\u00e7as submetidas a radiografias, obter imagens de alta qualidade com a menor radia\u00e7\u00e3o poss\u00edvel e criar um protocolo pedi\u00e1trico para uso de diferentes tipos de equipamentos digitais. <\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2425\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"tab\" aria-controls=\"elementor-tab-content-2425\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Microbiologia e doen\u00e7as infecciosas<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2425\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2425\"><p><strong>Tema do projeto:<\/strong> bact\u00e9rias que provocam infec\u00e7\u00f5es e s\u00e3o resistentes a medicamentos<br \/><strong>Objetivo:<\/strong> conhecer a epidemiologia da bact\u00e9ria <em>Staphylococcus aureus<\/em> resistente ao antibi\u00f3tico meticilina para adotar medidas de controle mais efetivas desse microrganismo, que \u00e9 um dos maiores causadores de infec\u00e7\u00e3o hospitalar no mundo. O projeto funciona junto ao <a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/?page_id=3152#5-10-3\" rel=\"noopener\">Programa de Stewardship (gerenciamento) de Antimicrobianos do Hospital Pequeno Pr\u00edncipe<\/a>.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2426\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"tab\" aria-controls=\"elementor-tab-content-2426\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Medicina molecular e bioinform\u00e1tica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2426\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2426\"><p><strong>Tema do projeto:<\/strong> busca de marcadores de resposta terap\u00eautica na leucemia linfobl\u00e1stica aguda (LLA)<br \/><strong>Objetivo:<\/strong> avaliar altera\u00e7\u00f5es gen\u00e9ticas de c\u00e9lulas leuc\u00eamicas e sua express\u00e3o g\u00eanica em pacientes pedi\u00e1tricos com LLA, no diagn\u00f3stico e ao longo do tratamento, buscando identificar poss\u00edveis marcadores iniciais de resposta terap\u00eautica. Simultaneamente, ser\u00e1 avaliada a microbiota intestinal dos pacientes, tamb\u00e9m no diagn\u00f3stico e ao longo do tratamento, para compreender o papel dessa microbiota na resposta ao tratamento e na suscetibilidade a infec\u00e7\u00f5es. Assim, ser\u00e1 poss\u00edvel tamb\u00e9m avaliar a intera\u00e7\u00e3o de fatores gen\u00e9ticos e imunol\u00f3gicos com a microbiota e a import\u00e2ncia dessas intera\u00e7\u00f5es na determina\u00e7\u00e3o do sucesso terap\u00eautico.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a1879df elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-toggle\" data-id=\"a1879df\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1691\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-1691\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Doen\u00e7as complexas e oncogen\u00e9tica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1691\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1691\"><p><strong>Tema do projeto:<\/strong> an\u00e1lise gen\u00e9tica de tecidos com sarcoma de Ewing<br \/><strong>Objetivo:<\/strong> identificar altera\u00e7\u00f5es de genes em pacientes que desenvolvem o sarcoma de Ewing, um tipo de c\u00e2ncer que ocorre no interior ou em torno dos ossos de crian\u00e7as e jovens adultos.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1692\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"tab\" aria-controls=\"elementor-tab-content-1692\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Terapia celular e farmacol\u00f3gica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1692\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1692\"><p><strong>Tema do projeto:<\/strong> terapia de microRNAs de c\u00e9lulas precursoras neuronais no tratamento da doen\u00e7a de Parkinson<br \/><strong>Objetivo:<\/strong> como parte do programa de Plataformas Inovadoras em Terapias Avan\u00e7adas, do Minist\u00e9rio da Sa\u00fade, o projeto para o desenvolvimento de novos tratamentos para a doen\u00e7a de Parkinson, que recebeu recursos em 2020, teve seus experimentos iniciados em 2021. O projeto busca o desenvolvimento de um nanomedicamento biol\u00f3gico seguro, a partir de produtos derivados das precursoras neuronais obtidas da diferencia\u00e7\u00e3o de c\u00e9lulas-tronco do cord\u00e3o umbilical humano.<\/p><p><strong>Tema do projeto:<\/strong> otimiza\u00e7\u00e3o da obten\u00e7\u00e3o de precursoras neuronais e seus derivados em material h\u00edbrido \u2013 biomaterial e grafeno<br \/><strong>Objetivo:<\/strong> otimizar a obten\u00e7\u00e3o de precursoras neuronais e seus derivados em material h\u00edbrido (membrana NFBX de biopol\u00edmero incorporada com nanopart\u00edculas de grafeno) para a maior produ\u00e7\u00e3o e expans\u00e3o celular no desenvolvimento de novas terapias para as doen\u00e7as neurodegenerativas e do neurodesenvolvimento. As c\u00e9lulas percebem o microambiente ao seu redor por meio da sinaliza\u00e7\u00e3o qu\u00edmica ou pela interpreta\u00e7\u00e3o de for\u00e7as f\u00edsicas, que podem ser geradas tanto de forma interna como de forma externa em resposta a propriedades f\u00edsicas como rigidez ou elasticidade do substrato, contratilidade celular ou, ainda, pela for\u00e7a gerada por c\u00e9lulas vizinhas. Essa capacidade das c\u00e9lulas de transformar est\u00edmulos mec\u00e2nicos em respostas qu\u00edmicas \u00e9 chamada de mecanotransdu\u00e7\u00e3o e \u00e9 essencial para modular o comportamento celular, influenciando o destino das c\u00e9lulas em rela\u00e7\u00e3o \u00e0 prolifera\u00e7\u00e3o, sobreviv\u00eancia, diferencia\u00e7\u00e3o e, at\u00e9 mesmo, nos processos de regenera\u00e7\u00e3o de tecidos e reparo de les\u00f5es. Por outro lado, o grafeno possui uma estrutura bidimensional, alta \u00e1rea de superf\u00edcie, alta condutividade el\u00e9trica, estabilidade qu\u00edmica e propriedades flexivas. Essas caracter\u00edsticas permitem que o grafeno seja capaz de imobilizar subst\u00e2ncias como metais, drogas, sondas fluorescentes e c\u00e9lulas, atraindo o interesse na medicina regenerativa. Estudos recentes demonstram que o grafeno, ou materiais \u00e0 base de grafeno, promovem ades\u00e3o, prolifera\u00e7\u00e3o e diferencia\u00e7\u00e3o de v\u00e1rios tipos de c\u00e9lulas, incluindo as c\u00e9lulas-tronco<\/p><p><strong>Tema do projeto:<\/strong> extra\u00e7\u00e3o do composto beta-glucana de cogumelos medicinais<br \/><strong>Objetivo:<\/strong> estudar meios de baixo custo para extrair a beta-glucana, presente em alguns tipos de cogumelo. Ela ativa o sistema imunol\u00f3gico e tem a\u00e7\u00e3o direta no tratamento da mucosite, inflama\u00e7\u00e3o da parte interna da boca e da garganta que pode acometer pacientes em tratamentos quimioter\u00e1picos.<\/p><p><strong>Tema do projeto:<\/strong> efeitos dos \u00e1cidos k\u00f3jico e glic\u00f3lico na produ\u00e7\u00e3o de melanina<br \/><strong>Objetivo:<\/strong> avaliar efeitos desses dois \u00e1cidos em c\u00e9lulas produtoras da melanina (prote\u00edna que determina a cor da pele), verificar se t\u00eam potencial de diminuir essa produ\u00e7\u00e3o e, assim, serem usados em tratamentos contra o melasma (hiperpigmenta\u00e7\u00e3o que causa manchas escuras na pele).<\/p><p><strong>Tema do projeto:<\/strong> transplante de medula \u00f3ssea em crian\u00e7as com fal\u00eancias medulares<br \/><strong>Objetivo:<\/strong> avaliar o perfil de pacientes com at\u00e9 5 anos de idade submetidos a transplante de c\u00e9lulas-tronco hematopoi\u00e9ticas de 1992 a 2020 em tr\u00eas institui\u00e7\u00f5es brasileiras, mostrar os resultados de sobrevida e descrever complica\u00e7\u00f5es precoces ou tardias ap\u00f3s a cirurgia.<\/p><p><strong>Tema do projeto:<\/strong> transplante de c\u00e9lulas-tronco em pacientes com erros inatos do metabolismo<br \/><strong>Objetivo:<\/strong> avaliar a sobrevida e as poss\u00edveis complica\u00e7\u00f5es ap\u00f3s o transplante de medula \u00f3ssea em crian\u00e7as com erros inatos do metabolismo. Essa condi\u00e7\u00e3o gen\u00e9tica prejudica o funcionamento correto da s\u00edntese de prote\u00ednas e pode causar desde v\u00f4mitos e infec\u00e7\u00f5es frequentes a doen\u00e7as g\u00e1stricas e problemas de crescimento. In\u00e9dita no Brasil, a an\u00e1lise se concentra em transplantados em seis hospitais pedi\u00e1tricos do pa\u00eds, entre 1988 e 2020.<\/p><p><strong>Tema do projeto:<\/strong> reincid\u00eancia de leucemias agudas ap\u00f3s transplante<br \/><strong>Objetivo:<\/strong> analisar o reaparecimento da doen\u00e7a e fatores de risco em pacientes com menos de 18 anos de idade que fizeram transplante de c\u00e9lulas-tronco hematopoi\u00e9ticas com doador. O foco do levantamento s\u00e3o crian\u00e7as e adolescentes submetidos ao procedimento entre 2010 e 2019 em tr\u00eas centros pedi\u00e1tricos brasileiros.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1693\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"tab\" aria-controls=\"elementor-tab-content-1693\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Terapia celular e farmacol\u00f3gica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1693\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1693\"><p><strong>terapia de microRNAs de c\u00e9lulas precursoras neuronais no tratamento da doen\u00e7a de Parkinson<\/strong><br \/>como parte do programa de Plataformas Inovadoras em Terapias Avan\u00e7adas, do Minist\u00e9rio da Sa\u00fade, o projeto para o desenvolvimento de novos tratamentos para a doen\u00e7a de Parkinson, que recebeu recursos em 2020, teve seus experimentos iniciados em 2021. O projeto busca o desenvolvimento de um nanomedicamento biol\u00f3gico seguro, a partir de produtos derivados das precursoras neuronais obtidas da diferencia\u00e7\u00e3o de c\u00e9lulas-tronco do cord\u00e3o umbilical humano.<\/p><p><strong>otimiza\u00e7\u00e3o da obten\u00e7\u00e3o de precursoras neuronais e seus derivados em material h\u00edbrido \u2013 biomaterial e grafeno<\/strong><br \/>otimizar a obten\u00e7\u00e3o de precursoras neuronais e seus derivados em material h\u00edbrido (membrana NFBX de biopol\u00edmero incorporada com nanopart\u00edculas de grafeno) para a maior produ\u00e7\u00e3o e expans\u00e3o celular no desenvolvimento de novas terapias para as doen\u00e7as neurodegenerativas e do neurodesenvolvimento. As c\u00e9lulas percebem o microambiente ao seu redor por meio da sinaliza\u00e7\u00e3o qu\u00edmica ou pela interpreta\u00e7\u00e3o de for\u00e7as f\u00edsicas, que podem ser geradas tanto de forma interna como de forma externa em resposta a propriedades f\u00edsicas como rigidez ou elasticidade do substrato, contratilidade celular ou, ainda, pela for\u00e7a gerada por c\u00e9lulas vizinhas. Essa capacidade das c\u00e9lulas de transformar est\u00edmulos mec\u00e2nicos em respostas qu\u00edmicas \u00e9 chamada de mecanotransdu\u00e7\u00e3o e \u00e9 essencial para modular o comportamento celular, influenciando o destino das c\u00e9lulas em rela\u00e7\u00e3o \u00e0 prolifera\u00e7\u00e3o, sobreviv\u00eancia, diferencia\u00e7\u00e3o e, at\u00e9 mesmo, nos processos de regenera\u00e7\u00e3o de tecidos e reparo de les\u00f5es. Por outro lado, o grafeno possui uma estrutura bidimensional, alta \u00e1rea de superf\u00edcie, alta condutividade el\u00e9trica, estabilidade qu\u00edmica e propriedades flexivas. Essas caracter\u00edsticas permitem que o grafeno seja capaz de imobilizar subst\u00e2ncias como metais, drogas, sondas fluorescentes e c\u00e9lulas, atraindo o interesse na medicina regenerativa. Estudos recentes demonstram que o grafeno, ou materiais \u00e0 base de grafeno, promovem ades\u00e3o, prolifera\u00e7\u00e3o e diferencia\u00e7\u00e3o de v\u00e1rios tipos de c\u00e9lulas, incluindo as c\u00e9lulas-tronco<\/p><p><strong>extra\u00e7\u00e3o do composto beta-glucana de cogumelos medicinais<\/strong><br \/>estudar meios de baixo custo para extrair a beta-glucana, presente em alguns tipos de cogumelo. Ela ativa o sistema imunol\u00f3gico e tem a\u00e7\u00e3o direta no tratamento da mucosite, inflama\u00e7\u00e3o da parte interna da boca e da garganta que pode acometer pacientes em tratamentos quimioter\u00e1picos.<\/p><p><strong>efeitos dos \u00e1cidos k\u00f3jico e glic\u00f3lico na produ\u00e7\u00e3o de melanina<\/strong><br \/>avaliar efeitos desses dois \u00e1cidos em c\u00e9lulas produtoras da melanina (prote\u00edna que determina a cor da pele), verificar se t\u00eam potencial de diminuir essa produ\u00e7\u00e3o e, assim, serem usados em tratamentos contra o melasma (hiperpigmenta\u00e7\u00e3o que causa manchas escuras na pele).<\/p><p><strong>transplante de medula \u00f3ssea em crian\u00e7as com fal\u00eancias medulares<\/strong><br \/>avaliar o perfil de pacientes com at\u00e9 5 anos de idade submetidos a transplante de c\u00e9lulas-tronco hematopoi\u00e9ticas de 1992 a 2020 em tr\u00eas institui\u00e7\u00f5es brasileiras, mostrar os resultados de sobrevida e descrever complica\u00e7\u00f5es precoces ou tardias ap\u00f3s a cirurgia.<\/p><p><strong>transplante de c\u00e9lulas-tronco em pacientes com erros inatos do metabolismo<\/strong><br \/>avaliar a sobrevida e as poss\u00edveis complica\u00e7\u00f5es ap\u00f3s o transplante de medula \u00f3ssea em crian\u00e7as com erros inatos do metabolismo. Essa condi\u00e7\u00e3o gen\u00e9tica prejudica o funcionamento correto da s\u00edntese de prote\u00ednas e pode causar desde v\u00f4mitos e infec\u00e7\u00f5es frequentes a doen\u00e7as g\u00e1stricas e problemas de crescimento. In\u00e9dita no Brasil, a an\u00e1lise se concentra em transplantados em seis hospitais pedi\u00e1tricos do pa\u00eds, entre 1988 e 2020.<\/p><p><strong>reincid\u00eancia de leucemias agudas ap\u00f3s transplante<\/strong><br \/>analisar o reaparecimento da doen\u00e7a e fatores de risco em pacientes com menos de 18 anos de idade que fizeram transplante de c\u00e9lulas-tronco hematopoi\u00e9ticas com doador. O foco do levantamento s\u00e3o crian\u00e7as e adolescentes submetidos ao procedimento entre 2010 e 2019 em tr\u00eas centros pedi\u00e1tricos brasileiros.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1694\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"tab\" aria-controls=\"elementor-tab-content-1694\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Neuroci\u00eancias<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1694\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1694\"><p><strong>Tema do projeto:<\/strong> efeitos do merc\u00fario t\u00f3xico na forma\u00e7\u00e3o de neur\u00f4nios<br \/><strong>Objetivo:<\/strong> analisar os efeitos de um tipo t\u00f3xico de merc\u00fario no crescimento e na diferencia\u00e7\u00e3o de neur\u00f4nios obtidos a partir de c\u00e9lulas-tronco, em busca de uma explica\u00e7\u00e3o para a doen\u00e7a de Parkinson.<\/p><p><strong>Tema do projeto:<\/strong> perfis neurol\u00f3gicos e gen\u00e9ticos de pacientes com mucolysacaridose III no Brasil<br \/><strong>Objetivo:<\/strong> estudar o impacto da mucopolissacaridose tipo III, tamb\u00e9m chamada de s\u00edndrome de Sanfilippo, no c\u00e9rebro e comportamento de crian\u00e7as e adolescentes.<\/p><p><strong>Tema do projeto:<\/strong> compara\u00e7\u00e3o do diagn\u00f3stico do Transtorno do Espectro autista (TEA) em pa\u00edses desenvolvidos e em desenvolvimento<br \/><strong>Objetivo:<\/strong> a pesquisa visa a a avaliar os m\u00e9todos, primeiros sintomas e quem os observa (pediatras, pais ou professores) do TEA em crian\u00e7as, e comparar os resultados de pa\u00edses desenvolvidos (com renda m\u00e9dia alta) com os de pa\u00edses em desenvolvimento (com renda baixa). Essa pesquisa pode clarificar quais os sintomas mais importantes e quem os observa primeiro, contribuindo para ajudar o tratamento precoce<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1695\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"tab\" aria-controls=\"elementor-tab-content-1695\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Imaginologia, prote\u00e7\u00e3o radiol\u00f3gica e radioterapia<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1695\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1695\"><p><strong>Tema do projeto:<\/strong> qualidade de imagem digital e t\u00e9cnicas radiogr\u00e1ficas em pediatria<br \/><strong>Objetivo:<\/strong> quantificar doses de radia\u00e7\u00e3o em crian\u00e7as submetidas a radiografias, obter imagens de alta qualidade com a menor radia\u00e7\u00e3o poss\u00edvel e criar um protocolo pedi\u00e1trico para uso de diferentes tipos de equipamentos digitais. <\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1696\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"tab\" aria-controls=\"elementor-tab-content-1696\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Microbiologia e doen\u00e7as infecciosas<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1696\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1696\"><p><strong>Tema do projeto:<\/strong> bact\u00e9rias que provocam infec\u00e7\u00f5es e s\u00e3o resistentes a medicamentos<br \/><strong>Objetivo:<\/strong> conhecer a epidemiologia da bact\u00e9ria Staphylococcus aureus resistente ao antibi\u00f3tico meticilina para adotar medidas de controle mais efetivas desse microrganismo, que \u00e9 um dos maiores causadores de infec\u00e7\u00e3o hospitalar no mundo. O projeto funciona junto ao Programa de Stewardship (gerenciamento) de Antimicrobianos do Hospital Pequeno Pr\u00edncipe.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1697\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"tab\" aria-controls=\"elementor-tab-content-1697\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\" class=\"elementor-toggle-title\">Medicina molecular e bioinform\u00e1tica<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1697\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-1697\"><p><strong>Tema do projeto:<\/strong> busca de marcadores de resposta terap\u00eautica na Leucemia Linfobl\u00e1stica Aguda (LLA)<br \/><strong>Objetivo:<\/strong> avaliar altera\u00e7\u00f5es gen\u00e9ticas de c\u00e9lulas leuc\u00eamicas e sua express\u00e3o g\u00eanica em pacientes pedi\u00e1tricos com LLA, ao diagn\u00f3stico e tamb\u00e9m ao longo do tratamento, buscando identificar poss\u00edveis marcadores iniciais de resposta terap\u00eautica. Simultaneamente, ser\u00e1 avaliada a microbiota ent\u00e9rica dos pacientes, tamb\u00e9m ao diagn\u00f3stico e ao longo do tratamento, para a compreens\u00e3o do papel desta microbiota na resposta do paciente ao tratamento e na susceptibilidade do mesmo a infec\u00e7\u00f5es. Assim, ser\u00e1 poss\u00edvel tamb\u00e9m a avalia\u00e7\u00e3o da intera\u00e7\u00e3o de fatores gen\u00e9ticos e imunol\u00f3gicos com a microbiota e a import\u00e2ncia destas intera\u00e7\u00f5es na determina\u00e7\u00e3o do sucesso terap\u00eautico.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1092026 elementor-widget elementor-widget-spacer\" data-id=\"1092026\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7880fb1\" data-id=\"7880fb1\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-de4914d elementor-widget elementor-widget-image\" data-id=\"de4914d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/IPP-psfepcfa76uhsx3u7e0bnbcxbthkwb19pcid0ly0jo.jpeg\" title=\"IPP\" alt=\"IPP\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e6ba14 elementor-widget elementor-widget-image\" data-id=\"3e6ba14\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/IPP-10-psfeqnf7owmtxf7kkybo3zhz131xl67ujt4n0g0bwk.jpeg\" title=\"IPP (10)\" alt=\"IPP (10)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a96c81a elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"a96c81a\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2ebe0f5\" data-id=\"2ebe0f5\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-db8018b elementor-widget elementor-widget-spacer\" data-id=\"db8018b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e66c122\" data-id=\"e66c122\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-65dc68b elementor-widget elementor-widget-spacer\" data-id=\"65dc68b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-254018c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"254018c\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a8b23d4\" data-id=\"a8b23d4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-59eba1a elementor-widget elementor-widget-spacer\" data-id=\"59eba1a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bca3269 elementor-widget elementor-widget-heading\" data-id=\"bca3269\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xxl\">Parcerias no Brasil \ne no mundo<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e223f7 elementor-widget elementor-widget-text-editor\" data-id=\"5e223f7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>A ci\u00eancia \u00e9 uma atividade coletiva, que depende muito da colabora\u00e7\u00e3o entre os cientistas. O Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe mant\u00e9m h\u00e1 anos diversas parcerias com institui\u00e7\u00f5es nacionais e internacionais, que j\u00e1 renderam muitos frutos.<\/p><p>Em 2021, foi firmado um acordo com a Thales, empresa francesa do setor tecnol\u00f3gico, para a cria\u00e7\u00e3o de algoritmos capazes de indicar progn\u00f3sticos de c\u00e2ncer por meio de intelig\u00eancia artificial. O Instituto tamb\u00e9m expandiu a parceria com a Universidade de Kharkiv (Ucr\u00e2nia) em um projeto para medir doses de radia\u00e7\u00e3o em crian\u00e7as submetidas a radiografias.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0f5389d elementor-hidden-mobile\" data-id=\"0f5389d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e16da95 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e16da95\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-b6f5abc\" data-id=\"b6f5abc\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ffa6565 elementor-widget elementor-widget-spacer\" data-id=\"ffa6565\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c2ab21 elementor-widget elementor-widget-heading\" data-id=\"6c2ab21\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">Parceiros nacionais<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-433cd1b elementor-widget elementor-widget-text-editor\" data-id=\"433cd1b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li>A.C.Camargo Cancer Center<\/li><li>Centro de Inova\u00e7\u00e3o e Ensaios Pr\u00e9-Cl\u00ednicos (CIEnP)<\/li><li>Centro de Produ\u00e7\u00e3o e Pesquisa de Imunobiol\u00f3gicos (CPPI)<\/li><li>Faculdades Pequeno Pr\u00edncipe<\/li><li>Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) \u2013 Instituto Carlos Chagas (ICC\/Fiocruz Paran\u00e1, em Curitiba)<\/li><li>Instituto de Tratamento do C\u00e2ncer Infantil (Itaci, em S\u00e3o Paulo)<\/li><li>Instituto Nacional de C\u00e2ncer (Inca)<\/li><li>Hospital de Amor (Barretos)<\/li><li>Hospital de Cl\u00ednicas da UFPR<\/li><li>Hospital de Cl\u00ednicas de Porto Alegre<\/li><li>Hospital do C\u00e2ncer de Cascavel (Uopeccan)<\/li><li>Hospital Erasto Gaertner<\/li><li>Hospital Israelita Albert Einstein (S\u00e3o Paulo)<\/li><li>Hospital Nossa Senhora das Gra\u00e7as<\/li><li>Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie<\/li><li>Novos Arranjos de Pesquisa e Inova\u00e7\u00e3o (NAPI-Gen\u00f4mica, em Guarapuava\/PR)<\/li><li>Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR)<\/li><li>Rede Gen\u00f4mica Nacional<\/li><li>Universidade Cat\u00f3lica de Pelotas (UCPel)<\/li><li>Universidade Ceuma<\/li><li>Universidade de S\u00e3o Paulo (USP)<\/li><li>Universidade do Estado de Santa Catarina (Udesc)<\/li><li>Universidade Estadual de Londrina (UEL)<\/li><li>Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF)<\/li><li>Universidade Estadual do Paran\u00e1 (Unespar)<\/li><li>Universidade Federal da Grande Dourados (UFGD)<\/li><li>Universidade Federal de Pernambuco (UFPE)<\/li><li>Universidade Federal de Santa Catarina (UFSC)<\/li><li>Universidade Federal de Santa Maria (UFSM)<\/li><li>Universidade Federal do Delta do Parna\u00edba (UFDPar)<\/li><li>Universidade Federal do Maranh\u00e3o (UFMA)<\/li><li>Universidade Federal do Paran\u00e1 (UFPR)<\/li><li>Universidade Federal do Rec\u00f4ncavo da Bahia (UFRB)<\/li><li>Universidade Federal do Rio de Janeiro (UFRJ)<\/li><li>Universidade Paranaense (Unipar)<\/li><li>Universidade Tecnol\u00f3gica Federal do Paran\u00e1 (UTFPR)<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ee59145\" data-id=\"ee59145\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-154856d elementor-widget elementor-widget-spacer\" data-id=\"154856d\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e935ede elementor-widget elementor-widget-image\" data-id=\"e935ede\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/08\/IPP-7.jpeg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"IPP (7)\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MzI1NSwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA4XC9JUFAtNy5qcGVnIn0%3D\">\n\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/IPP-7-pt5v9he843miggmi2yjwn2e2c4wse20akjhdfuxyfc.jpeg\" title=\"IPP (7)\" alt=\"IPP (7)\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-26d25dc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"26d25dc\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7e39356\" data-id=\"7e39356\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3049c0c elementor-widget elementor-widget-spacer\" data-id=\"3049c0c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-be83cdc elementor-widget elementor-widget-heading\" data-id=\"be83cdc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">Parceiros internacionais<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-84f5ca8 elementor-widget elementor-widget-text-editor\" data-id=\"84f5ca8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li>Centro M\u00e9dico da Universidade Loma Linda (EUA)<\/li><li>Icahn Escola de Medicina Mount Sinai (EUA)<\/li><li>INSERM U1163, Paris 5 (Fran\u00e7a)<\/li><li>Instituto de Farmacologia Molecular e Celular de Valbonne (Fran\u00e7a)<\/li><li>Instituto Imagine (Fran\u00e7a)<\/li><li>Instituto Nacional de Pediatria (M\u00e9xico)<\/li><li>Instituto Nacional do C\u00e2ncer (EUA)<\/li><li>King\u2019s College (Inglaterra)<\/li><li>St. Jude Children\u2019s Research Hospital (EUA)<\/li><li>Thales Group (Fran\u00e7a)<\/li><li>Universidade da Calif\u00f3rnia (EUA)<\/li><li>Universidade de Antioqu\u00eda (Col\u00f4mbia)<\/li><li>Universidade de Cagliari (It\u00e1lia)<\/li><li>Universidade de Ci\u00eancias Aplicadas (Alemanha)<\/li><li>Universidade de Kharkiv (Ucr\u00e2nia)<\/li><li>Universidade do Cabo Ocidental (\u00c1frica do Sul)<\/li><li>Universidade Emory (EUA)<\/li><li>Universidade Georgetown (EUA)<\/li><li>Universidade Georgia State (EUA)<\/li><li>Universidade Howard (EUA)<\/li><li>Universidade Rockefeller (EUA)<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7c149ac elementor-widget elementor-widget-image\" data-id=\"7c149ac\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_parceiros_internacionais.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"instituto_parceiros_internacionais\" e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTI5OCwidXJsIjoiaHR0cHM6XC9cL3BlcXVlbm9wcmluY2lwZS5vcmcuYnJcL3JlbGF0b3Jpb3dlYjIwMjFcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjJcLzA3XC9pbnN0aXR1dG9fcGFyY2Vpcm9zX2ludGVybmFjaW9uYWlzLmpwZyJ9\">\n\t\t\t\t\t\t\t<img width=\"800\" height=\"387\" src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_parceiros_internacionais.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_parceiros_internacionais.jpg 933w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_parceiros_internacionais-300x145.jpg 300w, https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/2022\/07\/instituto_parceiros_internacionais-768x371.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ded0afc elementor-widget elementor-widget-spacer\" data-id=\"ded0afc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e8ad236 elementor-hidden-mobile\" data-id=\"e8ad236\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-16064b5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"16064b5\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7201b0c\" data-id=\"7201b0c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-136150e elementor-widget elementor-widget-spacer\" data-id=\"136150e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0cc03ed elementor-widget elementor-widget-heading\" data-id=\"0cc03ed\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-xxl\">Artigos de impacto\n<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5697e89 elementor-widget elementor-widget-text-editor\" data-id=\"5697e89\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Veja os artigos dos pesquisadores do Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe publicados em 2021.<\/p><div>\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b01467 elementor-widget elementor-widget-text-editor\" data-id=\"9b01467\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Adrenocortical Carcinoma Steroid Profiles: In Silico Pan-Cancer Analysis of TCGA Data Uncovers Immunotherapy Targets for Improved Outcomes. <em>Frontiers in Endocrinology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3389\/fendo.2021.672319\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fendo.2021.672319<\/a><\/p><p>The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model. <em>Cancer Research<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1750\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1750<\/a><\/p><p>Pharmacological profile and effects of mitotane in adrenocortical carcinoma. <em>British Journal of Clinical Pharmacology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/bcp.14721\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/bcp.14721<\/a><\/p><p>Newborn Screening for the Detection of the TP53 R337H Variant and Surveillance for Early Diagnosis of Pediatric Adrenocortical Tumors: Lessons Learned and Way Forward. <em>Cancers<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/cancers13236111\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/cancers13236111<\/a><\/p><p>Curative therapy for hemoglobinopathies: an International Society for Cell &amp; Gene Therapy Stem Cell Engineering Committee review comparing outcomes, accessibility and cost of ex vivo stem cell gene therapy versus allogeneic hematopoietic stem cell transplantation. <em>Cytotherapy<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jcyt.2021.09.003\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jcyt.2021.09.003<\/a><\/p><p>Nursing diagnosis after hematopoietic stem cell transplant due to Fanconi anemia. <em>Revista Brasileira de Enfermagem<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1590\/0034-7167-2019-0864\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1590\/0034-7167-2019-0864<\/a><\/p><p>Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. II: CAR-T cell therapy for patients with CD19+ acute lymphoblastic leukemia. <em>Hematology, Transfusion and Cell Therapy<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.htct.2021.09.002\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.htct.2021.09.002<\/a><\/p><p>Ocular Manifestations in Patients with Fanconi Anemia: A Single Center Experience Including 106 Patients. <em>The Journal of Pediatrics<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jpeds.2021.11.013\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jpeds.2021.11.013<\/a><\/p><p>Kidney complications in 107 Fanconi anemia patients submitted to hematopoietic cell transplantation. <em>European Journal of Pediatrics<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1007\/s00431-021-04263-0\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1007\/s00431-021-04263-0<\/a><\/p><p>Impact of mother donor, peripheral blood stem cells and measurable residual disease on outcomes after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in children with acute leukaemia. <em>Bone Marrow Transplantation<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1038\/s41409-021-01453-0\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41409-021-01453-0<\/a><\/p><p>Analysis of baseline characteristics, disease burden and long-term follow-up of 167 patients with Paroxysmal Nocturnal Hemoglobinuria at a single center in Brazil. <em>Blood Cells, Molecules, and Diseases<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bcmd.2021.102605\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.bcmd.2021.102605<\/a><\/p><p>Therapy-related acute myeloid leukemia with KMT2A-SNX9 gene fusion associated with a hyperdiploid karyotype after hemophagocytic lymphohistiocytosis. <em>Cancer Genetics<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.cancergen.2021.05.001\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.cancergen.2021.05.001<\/a><\/p><p>Outcomes After Haploidentical Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide: A Systematic Review and Meta-Analysis Comparing Myeloablative with Reduced-Intensity Conditioning Regimens and Bone Marrow with Peripheral Blood Stem Cell Grafts. <em>Transplantation and Cellular Therapy<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jtct.2021.06.011\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jtct.2021.06.011<\/a><\/p><p>International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome. <em>Journal of Allergy and Clinical Immunology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2021.04.036\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jaci.2021.04.036<\/a><\/p><p>The impact of donor-specific anti-human leukocyte antigen antibodies in salvage haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide in patients with nonmalignant disorders. <em>HLA<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/tan.14277\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/tan.14277<\/a><\/p><p>Mortality among pediatric hematopoietic stem cell transplantation patients: Report from a single center in southern Brazil. <em>Pediatric Transplantation<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/petr.13944\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/petr.13944<\/a><\/p><p>A case series of medication-related fibrovascular hyperplasia following hematopoietic stem cell transplantation for Fanconi anemia. <em>Pediatric Transplantation<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/petr.13947\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/petr.13947<\/a><\/p><p>Self-perception of periodontal health status among individuals with Fanconi anemia. <em>Hematology, Transfusion and Cell Therapy<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.htct.2020.07.009\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.htct.2020.07.009<\/a><\/p><p>FLAG-sequential regimen followed by bone marrow transplantation for myelodysplastic syndrome or acute leukemia in patients with Fanconi anemia: a Franco-Brazilian study. <em>Bone Marrow Transplantation<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1038\/s41409-020-0994-2\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41409-020-0994-2<\/a><\/p><p>Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study. <em>Journal of Clinical Immunology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1007\/s10875-021-01066-8\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1007\/s10875-021-01066-8<\/a><\/p><p>CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking. <em>JCI Insight<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1172\/jci.insight.148652\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1172\/jci.insight.148652<\/a><\/p><p>Immunity and inflammatory biomarkers in COVID-19: A Systematic Review. <em>Reviews in Medical Virology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1002\/rmv.2199\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1002\/rmv.2199<\/a><\/p><p>Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. <em>Science Immunology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1126\/sciimmunol.abl4340\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1126\/sciimmunol.abl4340<\/a><\/p><p>A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection. <em>Nature Immunology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1038\/s41590-021-01030-z\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41590-021-01030-z<\/a><\/p><p>SARS-CoV-2 related MIS-C: A key to the viral and genetic causes of Kawasaki disease? <em>The Journal of Experimental Medicine<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1084\/jem.20210446\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1084\/jem.20210446<\/a><\/p><p>From your nose to your toes: a review of severe acute respiratory syndrome coronavirus 2 pandemic-associated pernio. <em>Journal of Investigative Dermatology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jid.2021.05.024\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jid.2021.05.024<\/a><\/p><p>Brazilian high school students conceptions about alcoholic beverages. <em>Cadernos de Educa\u00e7\u00e3o, Tecnologia e Sociedade<\/em>.<br \/><a href=\"https:\/\/brajets.com\/v3\/index.php\/brajets\/article\/view\/671\" target=\"_blank\" rel=\"noopener\">http:\/\/dx.doi.org\/10.14571\/brajets.v14.n1<\/a><\/p><p>Systematic review and single-centre toxicology study identified analgesics and benzodiazepines as the main causes of paediatric medication poisoning. <em>Acta Paediatrica<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/apa.15531\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/apa.15531<\/a><\/p><p>IQ alteration induced by lead in developed and underdeveloped\/developing countries: A systematic review and a meta-analysis. <em>Environmental Pollution<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.envpol.2021.118316\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.envpol.2021.118316<\/a><\/p><p>A gest\u00e3o de caso e a avalia\u00e7\u00e3o da vulnerabilidade materna como estrat\u00e9gia de enfrentamento ao \u00f3bito infantil no Brasil: o caso do Paran\u00e1. <em>Anais do Instituto de Higiene e Medicina Tropical<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.25761\/anaisihmt.374\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.25761\/anaisihmt.374<\/a><\/p><p>Is there an association of genetic polymorphisms of the catechol-O-methyltransferase gene (rs165656 and rs174675) and the 5-hydroxytryptamine receptor 2 A gene (rs4941573 and rs6313) with sleep bruxism in individuals with obstructive sleep apnea? <em>Archives of Oral Biology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.archoralbio.2021.105315\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.archoralbio.2021.105315<\/a><\/p><p>The Impact of Parkin as a Possible Future Biomarker in Five Solid Pediatric Tumors. <em>Journal of Molecular and Genetic Medicine<\/em>.<br \/><a href=\"https:\/\/www.hilarispublisher.com\/open-access\/the-impact-of-parkin-as-a-possible-future-biomarker-in-five-solid-pediatric-tumors.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/www.hilarispublisher.com\/open-access\/the-impact-of-parkin-as-a-possible-future-biomarker-in-five-solid-pediatric-tumors.pdf<\/a><\/p><p>Association between COVID-19 pregnant women symptoms severity and placental morphologic features. <em>Frontiers in Immunology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3389\/fimmu.2021.685919\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fimmu.2021.685919<\/a><\/p><p>Parkin and its Molecular Associations in Gliomas \u2013 A Systematic Review. <em>Surgical and Experimental Pathology.<\/em><br \/><a href=\"https:\/\/doi.org\/10.1186\/s42047-021-00093-4\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1186\/s42047-021-00093-4<\/a><\/p><p>Lung Neutrophilic Recruitment and IL-8\/IL-17A Tissue Expression in COVID-19. <em>Frontiers in Immunology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3389\/fimmu.2021.656350\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fimmu.2021.656350<\/a><\/p><p>Susceptibility to SARS-CoV-2 infection in patients undergoing chemotherapy and radiation therapy. <em>Journal of Infection and Public Health<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jiph.2021.03.008\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jiph.2021.03.008<\/a><\/p><p>Rhamnogalacturonan polysaccharide inhibits inflammation and oxidative stress and alleviates visceral pain. <em>Journal of Functional Foods<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jff.2021.104483\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jff.2021.104483<\/a><\/p><p>Beneficial effects of polysaccharides on the epithelial barrier function in intestinal mucositis. <em>Frontiers in Physiology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3389\/fphys.2021.714846\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fphys.2021.714846<\/a><\/p><p>Effectiveness of the polyphenols-rich Sedum dendroideum infusion on gastric ulcer healing in rats: roles of protective endogenous factors and antioxidant and anti-inflammatory mechanisms. <em>Journal of Ethnopharmacology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.jep.2021.114260\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jep.2021.114260<\/a><\/p><p>Editorial: Nutrition and Regulation of Gastrointestinal Homeostasis, Injuries and Disturbances. <em>Frontiers in Physiology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3389\/fphys.2021.803200\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fphys.2021.803200<\/a><\/p><p>The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis. <em>European Journal of Pharmacology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.ejphar.2020.173636\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.ejphar.2020.173636<\/a><\/p><p>Clinical effects of red wine on the effectiveness, sensitivity and periodontal inflammation induced by at-home bleaching. <em>Quintessence International<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3290\/j.qi.b1864313\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3290\/j.qi.b1864313<\/a><\/p><p>Monitoring of Peripheral Blood Leukocytes and Plasma Samples: A Pilot Study to Examine Treatment Response to Leflunomide in Rheumatoid Arthritis. <em>Pharmaceuticals<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/ph14020106\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/ph14020106<\/a><\/p><p>Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs. <em>Journal of Immunology Research<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1155\/2021\/9957451\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1155\/2021\/9957451<\/a><\/p><p>Genomic analysis of Limosilactobacillus fermentum ATCC 23271, a potential probiotic strain with anti-Candida activity. <em>Journal of Fungi<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/jof7100794\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/jof7100794<\/a><\/p><p>Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies. <em>Nutrients<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/nu13062008\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/nu13062008<\/a><\/p><p>Polysaccharides from Pleurotus eryngii: Selective extraction methodologies and their modulatory effects on THP-1 macrophages. <em>Carbohydrate Polymers<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.carbpol.2020.117177\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.carbpol.2020.117177<\/a><\/p><p>Fungal beta-glucans as adjuvants for treating cancer patients \u2013 A systematic review of clinical trials. <em>Clinical Nutrition<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.clnu.2020.11.029\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.clnu.2020.11.029<\/a><\/p><p>Evaluation of the Radiation Exposure in Sequential Head Tomographic Exams of Patients with Traumatic Brain Injury and Decompressive Craniectomy. <em>Radiation Protection Dosimetry<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1093\/rpd\/ncaa220\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1093\/rpd\/ncaa220<\/a><\/p><p>Entrance Skin Dose Evaluation in Pediatric Patients Undergoing Skull, Pelvis and Abdomen Radiographs. <em>Journal of Physics: Conference Series<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1088\/1742-6596\/1826\/1\/012044\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1088\/1742-6596\/1826\/1\/012044<\/a><\/p><p>Optimizaci\u00f3n de la protecci\u00f3n en radiologia y cardiologia intervencionista pediatrica em Am\u00e9rica Latina y el Caribe (OPRIPALC). <em>Journal of Physics: Conference Series<\/em>.<br \/><a href=\"https:\/\/johamsc.com\/wp-content\/uploads\/2022\/01\/P215-221-4.01JOHAMSC-UBEDA-044-21.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/johamsc.com\/wp-content\/uploads\/2022\/01\/P215-221-4.01JOHAMSC-UBEDA-044-21.pdf<\/a><\/p><p>Bixin attenuates mechanical allodynia, anxious and depressive-like behaviors associated with experimental diabetes counteracting oxidative stress and glycated hemoglobin. <em>Brain Research<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.brainres.2021.147557\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.brainres.2021.147557<\/a><\/p><p>Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus. <em>Frontiers in Physiology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3389\/fphys.2021.699220\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fphys.2021.699220<\/a><\/p><p>Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels. <em>Environmental Toxicology and Pharmacology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.etap.2021.103727\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.etap.2021.103727<\/a><\/p><p>Combined Biomaterials: Amniotic Membrane and Adipose Tissue to Restore Injured Bone as Promoter of Calcification in Bone Regeneration: Preclinical Model. <em>Calcified Tissue International<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1007\/s00223-020-00793-1\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1007\/s00223-020-00793-1<\/a><\/p><p>Nanostructured Cellulose-Gellan-Xyloglucan-Lysozyme Dressing Seeded with Mesenchymal Stem Cells for Deep Second-Degree Burn Treatment. International <em>Journal of Nanomedicine<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.2147\/IJN.S289868\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.2147\/IJN.S289868<\/a><\/p><p>Role of mononuclear stem cells and decellularized amniotic membrane in the treatment of skin wounds in rats. <em>Tissue Barriers<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1080\/21688370.2021.1982364\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1080\/21688370.2021.1982364<\/a><\/p><p>Beneficial Roles of Cellulose Patch-Mediated Cell Therapy in Myocardial Infarction: A Preclinical Study. <em>Cells<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/cells10020424\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/cells10020424<\/a><\/p><p>Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering. <em>Membranes<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/membranes11080606\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/membranes11080606<\/a><\/p><p>Natural Membrane Differentiates Human Adipose-Derived Mesenchymal Stem Cells to Neurospheres by Mechanotransduction Related to YAP and AMOT Proteins. <em>Membranes<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/membranes11090687\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/membranes11090687<\/a><\/p><p>Environmental Detection of SARS-CoV-2 Virus RNA in Health Facilities in Brazil and a Systematic Review on Contamination Sources. <em>International Journal of Environmental Research and Public Health<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/ijerph18073824\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/ijerph18073824<\/a><\/p><p>Bone-Marrow Stem Cells and Acellular Human Amniotic Membrane in a Rat Model of Heart Failure. <em>Life<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/life11090958\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/life11090958<\/a><\/p><p>Human Mesenchymal Stem Cells Seeded on the Natural Membrane to Neurospheres for Cholinergic-like Neurons. <em>Membranes<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/membranes11080598\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/membranes11080598<\/a><\/p><p>Tracheal Repair with Human Umbilical Cord Mesenchymal Stem Cells Differentiated in Chondrocytes Grown on an Acellular Amniotic Membrane: A Pre-Clinical Approach. <em>Life<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/life11090879\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/life11090879<\/a><\/p><p>Potential of Human Neural Precursor Cells in Diabetic Retinopathy Therapeutics \u2013 Preclinical Model. <em>Current Eye Research<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1080\/02713683.2021.2002909\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1080\/02713683.2021.2002909<\/a><\/p><p>Biodegradable nanoparticles loaded with levodopa and\/or curcumin for treatment of Parkinson\u2019s disease. <em>European Journal of Public Health<\/em>.<br \/><a href=\"https:\/\/academic.oup.com\/eurpub\/article\/31\/Supplement_2\/ckab120.070\/6336146\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/eurpub\/article\/31\/<br \/>Supplement_2\/ckab120.070\/6336146<\/a><\/p><p>Mesenchymal stem cells immortalization\u2019s and state-of-art: a systematic review and meta-analysis. <em>European Journal of Public Health<\/em>.<br \/><a href=\"https:\/\/academic.oup.com\/eurpub\/article\/31\/Supplement_2\/ckab120.058\/6336097\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/eurpub\/article\/31\/<br \/>Supplement_2\/ckab120.058\/6336097<\/a><\/p><p>The natural functional biopolymer matrix demonstrates to be a promise for safe cell therapy in Parkinson\u2019s disease. <em>European Journal of Public Health<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1093\/eurpub\/ckab120.104\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1093\/eurpub\/ckab120.104<\/a><\/p><p>Human Mesenchymal Stem Cells Seeded on the Natural Membrane to Neurospheres for Cholinergic-like Neurons. <em>Membranes<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/membranes11080598\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/membranes11080598<\/a><\/p><p>The induced dose of experimental autoimmune encephalomyelitis was not determinant and proportional to histopathological findings. <em>European Journal of Public Health<\/em>.<br \/><a href=\"https:\/\/academic.oup.com\/eurpub\/article\/31\/Supplement_2\/ckab120.080\/6336201\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/eurpub\/article\/31\/<br \/>Supplement_2\/ckab120.080\/6336201<\/a><\/p><p><em>Ilex paraguariensis<\/em> extract as an alternative to pain medications. <em>Acta Pharmaceutica<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.2478\/acph-2021-0029\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.2478\/acph-2021-0029<\/a><\/p><p>Phytochemical characterization and antimicrobial activity of Terminalia catappa and its inclusion in the preparation of PVA electrospun film with potential healing effect. <em>World Journal of Pharmacy and Pharmaceutical Sciences<\/em>.<br \/><a href=\"http:\/\/dx.doi.org\/10.20959\/wjpps20214-18739\" target=\"_blank\" rel=\"noopener\">http:\/\/dx.doi.org\/10.20959\/wjpps20214-18739<\/a><\/p><p>Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill. <em>Evidence-Based Complementary and Alternative Medicine<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1155\/2021\/6580458\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1155\/2021\/6580458<\/a><\/p><p>The Xpert\u00ae MTB\/RIF diagnostic test for pulmonary and extrapulmonary tuberculosis in immunocompetent and immunocompromised patients: Benefits and experiences over 2 years in different clinical contexts. <em>PLOS ONE<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0247185\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1371\/journal.pone.0247185<\/a><\/p><p>Emergence of Thymidine-Dependent Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Patients in Southern Brazil. <em>Microbiology Spectrum<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1128\/Spectrum.00614-21\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1128\/Spectrum.00614-21<\/a><\/p><p>Antimicrobial resistance in Aeromonas species isolated from aquatic environments in Brazil. <em>Journal of Applied Microbiology<\/em>.<br \/><a href=\"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/jam.14965\" target=\"_blank\" rel=\"noopener\">https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/jam.14965<\/a><\/p><p>QNBC Is Associated with High Genomic Instability Characterized by Copy Number Alterations and miRNA Deregulation. <em>International Journal of Molecular Sciences<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3390\/ijms222111548\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/ijms222111548<\/a><\/p><p>Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infection. <em>Immunobiology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.imbio.2021.152130\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.imbio.2021.152130<\/a><\/p><p>A panel of miRNAs as prognostic markers for African-American patients with triple negative breast cancer. <em>BMC Cancer<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1186\/s12885-021-08573-2\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1186\/s12885-021-08573-2<\/a><\/p><p>The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review. <em>Infection, Genetics and Evolution<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.meegid.2021.104832\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.meegid.2021.104832<\/a><\/p><p>Integrated analysis of label-free quantitative proteomics and bioinformatics reveal insights into signaling pathways in male breast cancer. <em>Genetics and Molecular Biology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1590\/1678-4685-GMB-2019-0410\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1590\/1678-4685-GMB-2019-0410<\/a><\/p><p>HPV-associated penile cancer: Impact of copy number alterations in miRNA\/mRNA interactions and potential druggable targets. <em>Cancer Biomarkers<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3233\/CBM-210035\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3233\/CBM-210035<\/a><\/p><p>Neurological Characteristics of Pediatric Glycogen Storage Disease. <em>Frontiers in Endocrinology<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.3389\/fendo.2021.685272\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3389\/fendo.2021.685272<\/a><\/p><p>Potential Risk Factors for Autism in Children Requiring Neonatal Intensive Care Unit. <em>Neuropediatrics<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1055\/s-0041-1726401\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1055\/s-0041-1726401<\/a><\/p><p>Neuropsychological and behavioural profiles of students with intellectual development disorder on parents and teachers\u2019 perceptions. <em>Journal of Intellectual Disability Research<\/em>.<br \/><a href=\"https:\/\/doi.org\/10.1111\/jir.12837\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1111\/jir.12837<\/a><\/p><p>Clinical and Neurological Course of Tuberous Sclerosis Complex in Children and Adolescents. <em>Annals of Pediatrics &amp; Child Health<\/em>.<br \/><a href=\"https:\/\/www.jscimedcentral.com\/Pediatrics\/pediatrics-9-1225.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/www.jscimedcentral.com\/Pediatrics\/<br \/>pediatrics-9-1225.pdf<\/a><\/p><p>GABAA receptor encephalitis associated with human parvovirus B19 virus infection: Case report. <em>Medicine<\/em>.<br \/><a href=\"http:\/\/dx.doi.org\/10.1097\/MD.0000000000026324\" target=\"_blank\" rel=\"noopener\">http:\/\/dx.doi.org\/10.1097\/MD.0000000000026324<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a153c8 elementor-widget elementor-widget-spacer\" data-id=\"1a153c8\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-96991ab\" data-id=\"96991ab\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c8dec57 elementor-widget elementor-widget-image\" data-id=\"c8dec57\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:80,&quot;sticky_effects_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/Dra_Libera-2-e1658238988225-przppu3chrjwhg0wtc6g85j2om7qvynesepv597zug.jpeg\" title=\"Dra_Libera (2)\" alt=\"Dra_Libera (2)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-582153e elementor-widget elementor-widget-image\" data-id=\"582153e\" data-element_type=\"widget\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:420,&quot;sticky_effects_offset&quot;:420,&quot;sticky_parent&quot;:&quot;yes&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img src=\"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-content\/uploads\/elementor\/thumbs\/IPP_2021-1-przq9f2avicyczkwgswn67ms7lp18ye3hc012s6qsm.jpeg\" title=\"IPP_2021 (1)\" alt=\"IPP_2021 (1)\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b178fe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1b178fe\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e0b9bb6\" data-id=\"e0b9bb6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-26b99fb elementor-widget elementor-widget-spacer\" data-id=\"26b99fb\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u201cAs vacinas [contra a COVID-19] foram desenvolvidas em tempo recorde \u2013 uma vit\u00f3ria da ci\u00eancia e da engenhosidade humana.\u201d Ant\u00f3nio Guterres, secret\u00e1rio-geral da ONU Produzindo o futuro A pandemia de COVID-19 evidenciou a import\u00e2ncia estrat\u00e9gica da pesquisa cient\u00edfica para preservar a vida. Por meio das vacinas contra o coronav\u00edrus, tamb\u00e9m mostrou na pr\u00e1tica como os [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/pages\/24"}],"collection":[{"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/comments?post=24"}],"version-history":[{"count":317,"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/pages\/24\/revisions"}],"predecessor-version":[{"id":5414,"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/pages\/24\/revisions\/5414"}],"wp:attachment":[{"href":"https:\/\/pequenoprincipe.org.br\/relatorioweb2021\/wp-json\/wp\/v2\/media?parent=24"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}