{"id":60,"date":"2020-04-08T23:36:16","date_gmt":"2020-04-09T02:36:16","guid":{"rendered":"http:\/\/pequenoprincipe.org.br\/newscovid19\/en\/?p=60"},"modified":"2020-05-21T15:55:56","modified_gmt":"2020-05-21T18:55:56","slug":"research-institute-team-integrates-worldwide-project-on-coronavirus","status":"publish","type":"post","link":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/2\/research-institute-team-integrates-worldwide-project-on-coronavirus\/","title":{"rendered":"Research Institute team integrates worldwide project on coronavirus"},"content":{"rendered":"\n
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A team from the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute is part of the \u201cCOVID Human Genetic Effort<\/a>\u201d, a worldwide effort of researchers who seek to understand, through genetic analysis, why some people develop severe forms of COVID-19 even though they are not part of the group risk. \u201cIt is a collaborative project that brings together immunologists from all over the world. We want to understand how and why some people are more susceptible than others to develop the severe form of the disease, as we see more and more deaths of young and apparently healthy people,\u201d explains the project coordinator at the institution, Carolina Prando.<\/p>\n\n\n\n

Two\nBrazilian teams are taking part in the initiative. The team of\nimmunologist Carolina will coordinate the work in the three states of\nthe South region. \u201cAs winter is more severe here and, we have many\nrespiratory infections caused by other viruses in this time of the\nyear, we imagine that the demands of this region will be greater,\u201d\nshe says. The other team is from the University of S\u00e3o Paulo (USP)\nand will bring data from other Brazilian states.<\/p>\n\n\n\n

The\nresearchers will sequence and analyze the genes of patients who need\nICUs. \u201cIn our case, we will collect material from patients at the\nPequeno Pr\u00edncipe Hospital and also from inpatients in ICUs of other\nhospitals in the South region who want to participate in the project\nwith us,\u201d she explains. The results will be compared with data from\nresearchers from other parts of the world.<\/p>\n\n\n\n

\u201cThe\nwork will have an immediate effect, which is the identification of\npatients who suffer from already known innate immunity errors. In\nthese cases, these patients will be able to receive specific\nguidelines and tailormade treatments for their immunological\ndiagnosis, in addition to the treatment they are receiving for\nCOVID-19,\u201d she observes. In Brazil, for example, the estimate is\nthat there are about 160,000 people with innate immunity errors.\nHowever, just over 2,000 are diagnosed.<\/p>\n\n\n\n

\u201cFurthermore,\nwhen we compare our results with the ones from other centers around\nthe world, we are able to find patterns that reveal new diseases,\nmore quickly,\u201d highlights the researcher. \u201cWith this project we\nwant to contribute to the construction of knowledge that will allow\nus to understand why the immune system of some people is more\nsusceptible than others for severe cases of COVID-19. Besides, new\nstrategies for the prevention and treatment of the disease may be\ndeveloped, avoiding so many deaths,\u201d she considers.<\/p>\n\n\n\n

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Fight against coronavirus<\/strong>
The Research Institute\u2019s participation in the \u201cCOVID Human Genetic Effort\u201d is one of the contributions of the Pequeno Pr\u00edncipe in the fight against the new coronavirus. The institution is also prepared for this confrontation in its health assistance unit, Pequeno Pr\u00edncipe Hospital, where all elective procedures (consultations and scheduled surgeries) have already been postponed, so that the institution has the physical capacity to serve boys and girls with COVID-19.<\/p>\n\n\n\n

However,\nthe suspension of elective activities shows a major financial\nchallenge for Pequeno Pr\u00edncipe. \u201cA significant part of these\nprocedures is covered by the supplementary health system (Health\nInsurance Plans), where we have a small operating margin. With the\nsuspension, we are estimating an additional deficit between R$ 15\nmillion (US$ 2.8 million) and R$ 20 million (US$ 3.8 million) this\nyear, in addition to the approximately R$ 33 million (US$ 6.2\nmillion) that we have accumulated in deficit every year due to the\ngap in the remuneration of procedures by the Public Health System,\u201d\nexplains the corporate director of the Complex, Jos\u00e9 \u00c1lvaro da\nSilva Carneiro.<\/p>\n\n\n\n

In\naddition, the Hospital is facing the worldwide price increase in the\nsupplies, especially in Personal Protective Equipment (PPE). There is\nalso the need to increase the number of employees working at the\nfront line of care, since all those who are classified as a risk\ngroup were preventively removed from their activities. \u201cAll of this\nis affecting our financial planning and, more than ever, we need the\nsupport of our investors,\u201d says the executive director of the\nHospital, Ety Cristina Forte Carneiro.<\/p>\n","protected":false},"excerpt":{"rendered":"

Main purpose is to understand why some people develop severe illness even without being in the risk group<\/p>\n","protected":false},"author":1,"featured_media":38,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-60","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-6","entry"],"_links":{"self":[{"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/posts\/60","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/comments?post=60"}],"version-history":[{"count":10,"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/posts\/60\/revisions"}],"predecessor-version":[{"id":320,"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/posts\/60\/revisions\/320"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/media\/38"}],"wp:attachment":[{"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/media?parent=60"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/categories?post=60"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pequenoprincipe.org.br\/newscovid19\/en\/wp-json\/wp\/v2\/tags?post=60"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}