{"id":1609,"date":"2023-05-24T16:31:39","date_gmt":"2023-05-24T19:31:39","guid":{"rendered":"https:\/\/pequenoprincipe.org.br\/newsano7\/en\/?p=1609"},"modified":"2023-05-25T10:42:54","modified_gmt":"2023-05-25T13:42:54","slug":"study-contributes-to-increasing-understanding-of-the-evolution-of-neuroblastoma","status":"publish","type":"post","link":"https:\/\/pequenoprincipe.org.br\/newsano7\/en\/4\/study-contributes-to-increasing-understanding-of-the-evolution-of-neuroblastoma\/","title":{"rendered":"Study contributes to increasing understanding of the evolution of neuroblastoma<\/strong>"},"content":{"rendered":"\n

Neuroblastoma is a tumor that affects the sympathetic nervous system, which is responsible for controlling functions that the body performs unconsciously, such as breathing and blood pressure. This tumor accounts for about 10% of all cases of childhood cancer and mainly affects babies in their first year of life.<\/strong><\/p>\n\n\n\n

The disease is quite complex due to several factors:<\/p>\n\n\n\n

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  1. has a high potential to spread (metastasize);<\/li>\n\n\n\n
  2. in many cases, the patient does not respond to existing treatments;<\/li>\n\n\n\n
  3. there are many genetic alterations involved in the disease.<\/li>\n<\/ol>\n\n\n\n

    All these characteristics make neuroblastoma cause a high mortality rate.<\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n

    A study carried out by scientists from the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute analyzed four types of microRNAs<\/strong> from patients with this type of tumor. The miRNAs are small molecules that act in cells, regulating the information contained in genes. They are involved, for example, in the way genes work, controlling how cancer cells proliferate, how they migrate from one part of the body to another, how they invade other areas or even how they kill other cells.<\/strong><\/p>\n\n\n\n

    What did the study find?<\/strong><\/p>\n\n\n\n

    The research sought to understand the role of these four types of microRNAs in the prognosis, treatment, and survival of patients with neuroblastoma. For this, samples of tumors that were stored in the Biobank of the Pequeno Pr\u00edncipe Hospital were studied.<\/p>\n\n\n\n

    The results obtained showed that these small molecules are associated to:<\/p>\n\n\n\n