{"id":1149,"date":"2026-05-21T09:59:27","date_gmt":"2026-05-21T12:59:27","guid":{"rendered":"https:\/\/pequenoprincipe.org.br\/newsano\/?post_type=news26en&p=1149"},"modified":"2026-05-22T20:01:49","modified_gmt":"2026-05-22T23:01:49","slug":"research-institute-study-points-to-effects-of-herbicide-combinations-on-human-intestinal-cells","status":"publish","type":"news26en","link":"https:\/\/pequenoprincipe.org.br\/newsano\/news26en\/research-institute-study-points-to-effects-of-herbicide-combinations-on-human-intestinal-cells\/","title":{"rendered":"Research Institute study points to effects of herbicide combinations on human intestinal cells"},"content":{"rendered":"
\n
\"\"
Photo credit: Magnific<\/figcaption><\/figure>\n<\/div>\n\n\n

Research conducted by scientists from the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute has brought new warnings regarding the impacts of combined exposure to herbicides widely used in agriculture. Published in the scientific journal Environmental Toxicology and Pharmacology<\/em>, the study demonstrated that the association between the herbicides dicamba and 2,4-D may cause more severe damage to human intestinal cells than exposure to each substance individually.<\/p>\n\n\n\n

The study evaluated the toxicological effects of the two compounds on human intestinal Caco-2 cells, internationally used in gastrointestinal health research. Researchers analyzed different cellular mechanisms related to toxicity, including oxidative stress, inflammation, cell death, and impairment of intestinal barrier function.<\/p>\n\n\n\n

Results showed that when combined, the herbicides caused more severe biological alterations than when assessed separately. Observed effects included increased oxidative stress, reduced cell viability, and greater induction of apoptosis \u2014 the programmed cell death process.<\/p>\n\n\n\n

Real-world exposure and health impacts<\/strong><\/p>\n\n\n\n

According to the researchers, the relevance of the study lies precisely in evaluating a scenario close to real life. In agricultural environments, herbicides are frequently used together to increase weed-control effectiveness, expanding possibilities of simultaneous exposure through water, food, and the environment.<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

Although many toxicological studies analyze isolated substances, scientists emphasize that chemical mixtures may produce different and potentially more aggressive effects on the body.<\/p>\n\n\n\n

\u201cThe research reinforces the importance of expanding studies on combined exposures, which are part of the population\u2019s environmental and dietary reality. Understanding these mechanisms is essential for advancing risk assessment and protecting human health,\u201d emphasizes researcher Izonete Cristina Guiloski, who led the study.<\/p>\n\n\n\n

Science focused on public health<\/strong><\/p>\n\n\n\n

The article also highlights the role of the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute in subjects connecting science, public health, and prevention. In addition to investigating pediatric diseases and treatments, the Institute develops research focused on environmental impacts and factors that may influence health throughout life.<\/p>\n\n\n\n

The study was conducted in partnership with researchers from the Federal University of Paran\u00e1, Pequeno Pr\u00edncipe College, and other Brazilian institutions, strengthening scientific collaboration around strategic public health topics.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research identified that combining substances amplifies cellular damage and reinforces the importance of evaluating combined chemical exposures<\/p>\n","protected":false},"featured_media":1174,"parent":0,"menu_order":0,"template":"","edicao10_en":[49],"class_list":["post-1149","news26en","type-news26en","status-publish","has-post-thumbnail","hentry","edicao10_en-49","entry"],"acf":[],"gutenberg_blocks":[{"blockName":"core\/image","attrs":{"id":1174,"sizeSlug":"large","linkDestination":"none","align":"center"},"innerBlocks":[],"innerHTML":"\n

\"\"
Photo credit: Magnific<\/figcaption><\/figure>\n","innerContent":["\n
\"\"
Photo credit: Magnific<\/figcaption><\/figure>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":[],"innerBlocks":[],"innerHTML":"\n

Research conducted by scientists from the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute has brought new warnings regarding the impacts of combined exposure to herbicides widely used in agriculture. Published in the scientific journal Environmental Toxicology and Pharmacology<\/em>, the study demonstrated that the association between the herbicides dicamba and 2,4-D may cause more severe damage to human intestinal cells than exposure to each substance individually.<\/p>\n","innerContent":["\n

Research conducted by scientists from the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute has brought new warnings regarding the impacts of combined exposure to herbicides widely used in agriculture. Published in the scientific journal Environmental Toxicology and Pharmacology<\/em>, the study demonstrated that the association between the herbicides dicamba and 2,4-D may cause more severe damage to human intestinal cells than exposure to each substance individually.<\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":[],"innerBlocks":[],"innerHTML":"\n

The study evaluated the toxicological effects of the two compounds on human intestinal Caco-2 cells, internationally used in gastrointestinal health research. Researchers analyzed different cellular mechanisms related to toxicity, including oxidative stress, inflammation, cell death, and impairment of intestinal barrier function.<\/p>\n","innerContent":["\n

The study evaluated the toxicological effects of the two compounds on human intestinal Caco-2 cells, internationally used in gastrointestinal health research. Researchers analyzed different cellular mechanisms related to toxicity, including oxidative stress, inflammation, cell death, and impairment of intestinal barrier function.<\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":[],"innerBlocks":[],"innerHTML":"\n

Results showed that when combined, the herbicides caused more severe biological alterations than when assessed separately. Observed effects included increased oxidative stress, reduced cell viability, and greater induction of apoptosis \u2014 the programmed cell death process.<\/p>\n","innerContent":["\n

Results showed that when combined, the herbicides caused more severe biological alterations than when assessed separately. Observed effects included increased oxidative stress, reduced cell viability, and greater induction of apoptosis \u2014 the programmed cell death process.<\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":{"fontSize":"small"},"innerBlocks":[],"innerHTML":"\n

Real-world exposure and health impacts<\/strong><\/p>\n","innerContent":["\n

Real-world exposure and health impacts<\/strong><\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":[],"innerBlocks":[],"innerHTML":"\n

According to the researchers, the relevance of the study lies precisely in evaluating a scenario close to real life. In agricultural environments, herbicides are frequently used together to increase weed-control effectiveness, expanding possibilities of simultaneous exposure through water, food, and the environment.<\/p>\n","innerContent":["\n

According to the researchers, the relevance of the study lies precisely in evaluating a scenario close to real life. In agricultural environments, herbicides are frequently used together to increase weed-control effectiveness, expanding possibilities of simultaneous exposure through water, food, and the environment.<\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/image","attrs":{"id":1128,"sizeSlug":"large","linkDestination":"none","align":"center"},"innerBlocks":[],"innerHTML":"\n

\"\"<\/figure>\n","innerContent":["\n
\"\"<\/figure>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":[],"innerBlocks":[],"innerHTML":"\n

Although many toxicological studies analyze isolated substances, scientists emphasize that chemical mixtures may produce different and potentially more aggressive effects on the body.<\/p>\n","innerContent":["\n

Although many toxicological studies analyze isolated substances, scientists emphasize that chemical mixtures may produce different and potentially more aggressive effects on the body.<\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":[],"innerBlocks":[],"innerHTML":"\n

\u201cThe research reinforces the importance of expanding studies on combined exposures, which are part of the population\u2019s environmental and dietary reality. Understanding these mechanisms is essential for advancing risk assessment and protecting human health,\u201d emphasizes researcher Izonete Cristina Guiloski, who led the study.<\/p>\n","innerContent":["\n

\u201cThe research reinforces the importance of expanding studies on combined exposures, which are part of the population\u2019s environmental and dietary reality. Understanding these mechanisms is essential for advancing risk assessment and protecting human health,\u201d emphasizes researcher Izonete Cristina Guiloski, who led the study.<\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":{"fontSize":"small"},"innerBlocks":[],"innerHTML":"\n

Science focused on public health<\/strong><\/p>\n","innerContent":["\n

Science focused on public health<\/strong><\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":[],"innerBlocks":[],"innerHTML":"\n

The article also highlights the role of the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute in subjects connecting science, public health, and prevention. In addition to investigating pediatric diseases and treatments, the Institute develops research focused on environmental impacts and factors that may influence health throughout life.<\/p>\n","innerContent":["\n

The article also highlights the role of the Pel\u00e9 Pequeno Pr\u00edncipe Research Institute in subjects connecting science, public health, and prevention. In addition to investigating pediatric diseases and treatments, the Institute develops research focused on environmental impacts and factors that may influence health throughout life.<\/p>\n"]},{"blockName":null,"attrs":[],"innerBlocks":[],"innerHTML":"\n\n","innerContent":["\n\n"]},{"blockName":"core\/paragraph","attrs":[],"innerBlocks":[],"innerHTML":"\n

The study was conducted in partnership with researchers from the Federal University of Paran\u00e1, Pequeno Pr\u00edncipe College, and other Brazilian institutions, strengthening scientific collaboration around strategic public health topics.<\/p>\n","innerContent":["\n

The study was conducted in partnership with researchers from the Federal University of Paran\u00e1, Pequeno Pr\u00edncipe College, and other Brazilian institutions, strengthening scientific collaboration around strategic public health topics.<\/p>\n"]}],"yoast_head":"\nResearch Institute study points to effects of herbicide combinations on human intestinal cells - Newsletter HPP<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pequenoprincipe.org.br\/newsano\/news26en\/research-institute-study-points-to-effects-of-herbicide-combinations-on-human-intestinal-cells\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Institute study points to effects of herbicide combinations on human intestinal cells - Newsletter HPP\" \/>\n<meta property=\"og:description\" content=\"Research identified that combining substances amplifies cellular damage and reinforces the importance of evaluating combined chemical exposures\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pequenoprincipe.org.br\/newsano\/news26en\/research-institute-study-points-to-effects-of-herbicide-combinations-on-human-intestinal-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsletter HPP\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-22T23:01:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pequenoprincipe.org.br\/newsano\/wp-content\/uploads\/2026\/05\/PP_News_Ed_Maio2026_Materia3_1-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1703\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/pequenoprincipe.org.br\/newsano\/news26en\/research-institute-study-points-to-effects-of-herbicide-combinations-on-human-intestinal-cells\/\",\"url\":\"https:\/\/pequenoprincipe.org.br\/newsano\/news26en\/research-institute-study-points-to-effects-of-herbicide-combinations-on-human-intestinal-cells\/\",\"name\":\"Research Institute study points to effects of herbicide combinations on human intestinal cells - 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